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Sampling
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Was the study design appropriate to answer the research question?
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Was the sampling method appropriate?
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Did the study report how many people were approached and how many agreed to take part?
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Do those that participate have similar characteristics to those that refused (for example, age, gender, comorbidities, how they were approached)?
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Is the sample size adequate?
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Did the study describe how the sample size was determined?
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Was a suitable definition of TIA/minor stroke used?
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If applicable, was the control group comparable to cases (consider suitability, recruitment and baseline characteristics)?
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Did the study demonstrate if the outcomes were present before the TIA/minor stroke (for example, history of depression)?
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Measurement
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Was a suitable measurement for outcome used?
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Has the outcome measure been validated for the population?
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Was the outcome measure cut-off score predefined?
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Was the outcome measure administration suitable (for example, self reported, investigator interview)?
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Were potential confounding variables measured?
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Attrition
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Were numbers of dropouts/withdrawals documented at each time point?
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Were reasons given for dropouts/withdrawals?
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Analysis
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Were all outcomes reported?
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Were confounding variables adjusted for?
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