Outcome: | Â | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | GRADE factors |  | |||||||||||
Prognostic factors | Number of participants | Number of studies | Number of cohorts | Estimated effect size (95% confidence interval) | Phase | Study limitations | Inconsistency | Indirectness | Imprecision | Publication bias | Moderate/large effect size | Dose effect | Overall quality |