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Table 1 Definitions of the four quality categories according to the original Grading of Recommendations Assessment, Development and Evaluation (GRADE)[16], applicable to the modified GRADE

From: Judging the quality of evidence in reviews of prognostic factor research: adapting the GRADE framework

High quality We are very confident that the true effect lies close to that of the estimate of the effect
Moderate quality We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low quality Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect
Very low quality We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect
  1. Reprinted from [16] with permission from Elsevier.