Medication(s)

Naranjo score

Kramer score

WHO score


Biologics

Adalimumab

Possible

Possible

Possible

Certolizumab pegol

No use reported in any case report

Infliximab

Possible

Possible

Possible

Natalizumab

Possible

Possible

Possible

Ustekinumab

Possible

Possible

Possible

Antimetabolites

6mercaptopurine

Possible

Possible

Possible

Azathioprine

Possible

Possible

Possible

Aminosalicylates

Balsalazide

Possible

Unlikely

Possible

Mesalamine

Possible

Unlikely

Possible

Sulfasalazine

Possible

Unlikely

Possible

Corticosteroids

Budesonide

Possible

Unlikely

Possible

Hydrocortisone

Possible

Unlikely

Possible

Prednisone

Possible

Unlikely

Possible

Prednisolone

Possible

Unlikely

Possible

Corticosteroid unspecified

Possible

Unlikely

Possible

Other medications

Cyclosporine

Possible

Possible

Possible

Metronidazole

Possible

Unlikely

Possible

Nitrofurantoin

Possible

Unlikely

Possible

Piperacillin/tazobactam

Possible

Unlikely

Possible

Doxycycline

Possible

Unlikely

Possible

Ciprofloxacin

Possible

Unlikely

Possible

 Possible, all cases reporting that medication received a score of ‘possible’ using that particular causality assessment; unlikely, all cases reporting that medication received a score of ‘unlikely’ using that particular causality assessment. WHO, World Health Organization.