Timeline of medication approval by the Food and Drug Administration (FDA) and occurrence of hepatosplenic T-cell lymphoma (HSTCL). Includes 37 unique cases and nine cases with insufficient reporting, for a total of 46 cases. Each box includes a unique case by year the case was reported. The horizontal axis indicates the year the case was diagnosed. The numbers in each square are ordered oldest to youngest age at HSTCL diagnosis. They match up to the numbers with detailed case information in Additional file 2: Table S2. Vertical arrows indicate years that the particular medications were approved by the FDA. Ustekinumab is not approved by the FDA for Crohn’s disease. The numbers within each box refer to case numbers in Additional file 2: Table S2. Patients were reported through 25 January 2011 (published) and December 2010 (AERS). *Date of case reported as 2007 to 2008. **Date of case reported as 2000 to 2009. AERS, Adverse Event Reporting System; FDA, Food and Drug Administration; HSTCL, hepatosplenic T-cell lymphoma.