Figure 4
Impact of study design characteristics. The effect of the aggregate quality score (A), type of ischaemia (B), anaesthetic used during the induction of ischaemia (C), the time of administration (D), the drug dose (E) and the sex of the animals (F) on the estimates of efficacy measured as improvement in lesion size. Error bars represent 95% CI and bar widths represent the log of the number of animals. The horizontal error bar represents the global estimate of efficacy for lesion size and its 95% CI.