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Table 2 Quality assessment tool

From: Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: protocol for a systematic review

1. Study design (selection score)  
 a. Prospective clinical studies (any type)  
  - Consecutive enrolment 2
  - Unspecified/random enrolment 1
 b. Autopsy studies  
  - Consecutive enrolment 2
  - Unspecified/random enrolment 1
 c. Retrospective reviews (including subgroup analysis) 1
 d. Review/editorial 0
 e. Case report 0
2. Study objectives (selection score)  
 a. Clear inclusion criteria  
  - Aim related to PCP prevalence or outcomes 3
  - Related to OIs/general morbidity/respiratory disease but not specific to PCP 2
  - Unrelated to clinical PCP prevalence 1
 b. Unclear inclusion criteria 1
3. Diagnosisa (quality of outcome ascertainment)  
 a. Laboratory-confirmed (any specified method/specimen) 2
 b. Clinical case definition (consistent with WHO guidelines) 1
 c. Not specified 0
4. Denominator  
 a. Raw data denominator 2
 b. Calculated denominator 1
 c. No/unclear denominator/investigated < 20% of cohort for PCP/ exclusion group 0
5. Numerator (PCP numbers)  
 a. Raw data numerator 2
 b. Calculated numerator 1
 c. No/unclear numerator (clinical PCP not mentioned/tested) 0
6. Assessment of bias (low, high or unclear risk)  
 a. Attrition bias
  - Amount, nature or handling of incomplete outcome data
 b. Selection bias
  - Representativeness of the cases/cohort (clear reasons for and rates of non-inclusion)
  1. aDo not include data from clinical episodes of PCP if no case definition provided (even if study otherwise qualifies).