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Table 1 Power to determine the number of studies needed to show a moderator effect in a given meta-analysis dataset

From: Risk of bias: a simulation study of power to detect study-level moderator effects in meta-analysis

 

Proportion of studies (%) with positive expression of moderator (for example, ‘high quality’)

Studies ( n )

0.5

0.3

0.2

0.1

Moderator effect = 0

200

6

6

5

6

400

6

5

6

5

600

5

6

6

6

800

6

5

6

7

Moderator effect = 0.1

200

24

22

22

13

400

45

40

33

21

600

65

54

48

29

800

75

69

53

39

Moderator effect = 0.2

200

75

67

57

32

400

95

93

84

60

600

100

99

96

78

800

100

100

98

90

  1. Extrapolated from random sample of 200 RCTs, I2 = 92%, τ2 = 0.285; mean sample size 132; alpha = 0.05; in the absence of a moderator effect (moderator effect = 0), the power should vary around 5%.