Survival of patients with non-small cell lung cancer without treatment: a systematic review and meta-analysis

Table 2 Characteristics of studies included in the review

Study	N	Study period (years)	Disease Stage		Histology			Male	Median Age (years)
Study	N	Study period (years)	I	II	squamous	adeno	large-cell	Male	Median Age (years)
(a) Cohort studies
Raz 2007	1432	13	1432	NR	460	419	89	747	74
Wisnivesky 2007^a	2344	8	NR	NR	NR	NR	NR	1292	NR
Chadha 2005	39	11	23	13	18	88	5	4	77
Henschke 2003	131	7	131	NR	NR	NR	NR	NR	NR
McGarry 2002^a	49	5	NR	NR	NR	NR	NR	49	NR
Vrdoljak 1994	130	7	55	56	61	35	34	120	60
Hyde 1973	293	8	NR	NR	NR	NR	NR	NR	NR
Total/(Range)	4418	(5 to 13)	1641	68	539	542	128	2211
(b) RCTs			III	IV
Goss 2009^c	101	2 (0.23)	17	84	25	46	11	61	76
Anderson 2000	150	2	92	58	NR	NR	NR	91	64
ELVIS 1999^c	78	1 (1.08)	22	56	33	29	3	69	74^b
Cullen 1999^c	176	8 (2.17)	88	88	103	42	6	122	64
Thongprasert 1999	98	4	49	49	31	49	12	NR	60
Helsing 1998^c	26	5 (3.33)	3	23	5	17	4	18	65
Cartei 1993	50	7	NR	50	25	17	8	36	57
Leung 1992^c	66	4 (3.58)	58	NR	31	18	7	48	62
Cellerino 1991	61	3	61	NR	38	18	5	59	62
Quoix 1991	22	3	NR	22	NR	NR	NR	NR	NR
Kaasa 1991	43	3	NR	43	16	16	11	31	62^b
Ganz 1989	26	2	NR	26	9	17	NR	23	NR
Rapp 1988	50	3	50	NR	12	24	12	38	58
Cormier 1982	17	2	17	NR	8	2	6	16	60
Laing 1975	67	2	15	20	23	5	9	59	64
Total/(Range)	1031	(1 to 8)	472	519	359	300	94	671	(57 to 76)

N = Sample size or number of participants enrolled; NR = data not reported; adeno, = adenocarcinoma; squamous, = squamous cell carcinoma; large-cell, = large-cell carcinoma; ^asample includes stage I and II cancer; ^brecorded mean age where median age was not reported or not extractable^, ^cmedian follow-up in parenthesis.

ISSN: 2046-4053