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Table 2 Results of included studies

From: F-18-fluoro-2-deoxyglucose positron emission tomography (PET) and PET/computed tomography imaging in primary staging of patients with malignant melanoma: a systematic review

Study

Indication and index test

TP

FN

FP

TN

Sensitivity (%) (95% CI)

Specificity (%) (95% CI)

Rinne and colleagues [22]

N-staging and M-staging

PET

4

0

11

37

100 (40 to 100)

77 (63 to 88)

Crippa and colleagues [27]

N-staging

PET

17

2

3

16

90 (66.9 to 98.7)b

84 (60.4 to 96.6)b

Eigtved and colleagues [24]

M-staging

PET

28

1

4

5

97 (82 to 100)

56 (21 to 86)

Klein and colleagues [21]

N-staging

PET

2

1

0

14

67 (9.4 to 99.2)b

100 (76.8 to 100)b

Acland and colleagues [18]

N-staging

PET

0a

14a

7a

29a

0 (0 to 23.2)b

80,6b (64.0 to 91.8)b

Belhocine and colleagues [19]

N-staging

PET

1a

5a

1a

14b

16.7b (0.4 to 64.1)b

93.3b (68.1 to 99.8)b

Reinhardt and colleagues [29]

M-staging

PET

23

2

1

41

92 (74.0 to 99.0)b

98 (87.4 to 99.9)b

Hafner and colleagues [25]

M-staging

PET

0

0

2

98

98 d (93.0 to 99.8)d

N-staging

PET

2

24

0

74

8 (0.9 to 25.1)b

100 (95.1 to 100)b

Fink and colleagues [20]

N-staging

PET

1

7

0

40

13 (0 to 53)

100 (91 to 100)

Vereecken and colleagues [26]

N-staging

PET

4a

6a

27a

6a

40.0b (12.2 to 73.8)b

18.2b (7.0 to 35.5)b

Brady and colleagues [45]

N-staging and M-staging

PET

30

14

5

54

68 (52 to 81)

92 (81 to 97)

Maubec and colleagues [28]

N-staging and M-staging

PET/CT

1b

5b

5

14

17 (0.4b to 64)

74 (49 to 91)

Strobel and colleagues [36]

N-staging and M-staging

PET/CT

45

8

3

68

85 (72.4 to 93.3)b

96 (88.1 to 99.1)b

PET/CT and separate CT

52

1

4

67

98 (89,9 to 100)b

94 (86.2 to 98.4)b

Singh and colleagues [23]

N-staging

PET/CT

2

12

2

36

14.3 (2.5 to 44) b

94.7 (81 to 99)

Bastiaannet and colleagues [35]

M-staging

PET

68

11

11

161

86.1b (76.5 to 92.8)b

93.6b (88.8 to 96.8)b

CT

61

17

11

162b

78.2b (67.4 to 86.8)b

93.6b (88.9 to 96.8)b

Veit-Haibach and colleagues [37]

N-staging

PET/CT

5b

8

0

43b

38.5 (14 to 68)

100 (92 to 100)

PET

5b

8

0

43b

38.5 (14 to 68)

100 (92 to 100)

CT

3b,c

10

0

43b,c

23.1 (5 to 53)

100 (92 to 100)

M-staging

PET/CT

5b

7

3

41b

41.7 (15 to 72)

93.2 (81 to 99)

PET

4b

8

4

40 b

33.3 (9 to 65)

90.9 (78 to 97)

CT

3b,c

9

3

41b,c

25.0 (5 to 57)

93.2 (81 to 99)

Aukema and colleagues [34]

N-staging

PET/CT

26

4

1

39

86.7b (69.3 to 96.2)b

97.5b (86.8 to 99.9)b

  1. CI, confidence interval; CT, computed tomography; FN, false-negative; FP, false-positive; PET, positron emission tomography; TN, true-negative; TP, true-positive;
  2. aData were extracted from primary study.
  3. bOur own calculation.
  4. cThe combination of TP and TN is reported in Table 3 of the study publication. Our own calculation of these values was possible because of the additional information provided in the publication.