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Table 2 Results of included studies

From: F-18-fluoro-2-deoxyglucose positron emission tomography (PET) and PET/computed tomography imaging in primary staging of patients with malignant melanoma: a systematic review

Study Indication and index test TP FN FP TN Sensitivity (%) (95% CI) Specificity (%) (95% CI)
Rinne and colleagues [22] N-staging and M-staging PET 4 0 11 37 100 (40 to 100) 77 (63 to 88)
Crippa and colleagues [27] N-staging PET 17 2 3 16 90 (66.9 to 98.7)b 84 (60.4 to 96.6)b
Eigtved and colleagues [24] M-staging PET 28 1 4 5 97 (82 to 100) 56 (21 to 86)
Klein and colleagues [21] N-staging PET 2 1 0 14 67 (9.4 to 99.2)b 100 (76.8 to 100)b
Acland and colleagues [18] N-staging PET 0a 14a 7a 29a 0 (0 to 23.2)b 80,6b (64.0 to 91.8)b
Belhocine and colleagues [19] N-staging PET 1a 5a 1a 14b 16.7b (0.4 to 64.1)b 93.3b (68.1 to 99.8)b
Reinhardt and colleagues [29] M-staging PET 23 2 1 41 92 (74.0 to 99.0)b 98 (87.4 to 99.9)b
Hafner and colleagues [25] M-staging PET 0 0 2 98 98 d (93.0 to 99.8)d
N-staging PET 2 24 0 74 8 (0.9 to 25.1)b 100 (95.1 to 100)b
Fink and colleagues [20] N-staging PET 1 7 0 40 13 (0 to 53) 100 (91 to 100)
Vereecken and colleagues [26] N-staging PET 4a 6a 27a 6a 40.0b (12.2 to 73.8)b 18.2b (7.0 to 35.5)b
Brady and colleagues [45] N-staging and M-staging PET 30 14 5 54 68 (52 to 81) 92 (81 to 97)
Maubec and colleagues [28] N-staging and M-staging PET/CT 1b 5b 5 14 17 (0.4b to 64) 74 (49 to 91)
Strobel and colleagues [36] N-staging and M-staging PET/CT 45 8 3 68 85 (72.4 to 93.3)b 96 (88.1 to 99.1)b
PET/CT and separate CT 52 1 4 67 98 (89,9 to 100)b 94 (86.2 to 98.4)b
Singh and colleagues [23] N-staging PET/CT 2 12 2 36 14.3 (2.5 to 44) b 94.7 (81 to 99)
Bastiaannet and colleagues [35] M-staging PET 68 11 11 161 86.1b (76.5 to 92.8)b 93.6b (88.8 to 96.8)b
CT 61 17 11 162b 78.2b (67.4 to 86.8)b 93.6b (88.9 to 96.8)b
Veit-Haibach and colleagues [37] N-staging PET/CT 5b 8 0 43b 38.5 (14 to 68) 100 (92 to 100)
PET 5b 8 0 43b 38.5 (14 to 68) 100 (92 to 100)
CT 3b,c 10 0 43b,c 23.1 (5 to 53) 100 (92 to 100)
M-staging PET/CT 5b 7 3 41b 41.7 (15 to 72) 93.2 (81 to 99)
PET 4b 8 4 40 b 33.3 (9 to 65) 90.9 (78 to 97)
CT 3b,c 9 3 41b,c 25.0 (5 to 57) 93.2 (81 to 99)
Aukema and colleagues [34] N-staging PET/CT 26 4 1 39 86.7b (69.3 to 96.2)b 97.5b (86.8 to 99.9)b
  1. CI, confidence interval; CT, computed tomography; FN, false-negative; FP, false-positive; PET, positron emission tomography; TN, true-negative; TP, true-positive;
  2. aData were extracted from primary study.
  3. bOur own calculation.
  4. cThe combination of TP and TN is reported in Table 3 of the study publication. Our own calculation of these values was possible because of the additional information provided in the publication.