Study | DIPOL | AVID | RESIST | TULIP | OPTICUS |
---|---|---|---|---|---|
Enrolling years | 2000 to 2002 | 1995 to 1998 | 1995 to 1997 | 1991 to 2001 | 1996 to 1998 |
Randomized | Yes | Yes | Yes | Yes | Yes |
- Blinded? | Yes | Yes | N/A | N/A | Yes |
- When? | Pre-intervention | Pre-intervention | Post-intervention | Pre-intervention | Pre-intervention |
Intention-to-treat analysis | No | Yes | No | Yes | Yes |
Exclusion criteria | |||||
- Long lesions | Yes (> 25 mm) | No | Yes (> 15 mm) | No | Yes (> 25 mm) |
- Bifurcation | Yes | No | No | Yes | Yes |
- Left main coronary artery | Yes | Yes | No | No | Yes |
- Chronic total occlusion | Yes | Yes | Yes | Yes | No |
- Recent acute coronary syndrome | Yes | No (except MI with TIMI flow grade < 3) | Yes | Yes | Yes |
- Small vessels | Yes (≤ 2.75 mm) | Yes (< 2.5 mm) | Yes (< 3 mm) | Yes (< 3 mm) | Yes (< 2.5 mm) |
- Others | Age < 18 and > 70 y; extensive calcification; saphenous vein graft lesions | Age < 18 y; non-covered dissection; large vessels (> 3.25 mm) | Previous CABG | Focal (< 20 mm) or ostial lesions | |
Pre-intervention IVUS | Yes | No | No | Yes | Yes |
Post-intervention IVUS | Yes | Yes | Yes | Yes | Yes |
PCI success criteria | Stent CSA/average CSA > 80%, complete apposition, stent CSA > 7.5 mm2 | Stent CSA/distal CSA > 90%, complete apposition, no dissection | Stent CSA/average CSA > 80% | Stent MLD/average MLD > 80%, complete apposition, stent CSA ≥ distal CSA | Stenosis < 10% and MUSIC study criteria [10] |
- PCI success by IVUS,% | 96 | 63 | 61 | 89 | 82.2 and 56 (MUSIC) |
Clinical follow-up, months | 6 | 12 | 18 | 12 | 12 |
Angiographic follow-up, months | 6* | 6 (com USIC) | 6 | 6 | |
MACE | Death, nonfatal MI, repeat revascularization† | Without explicit criteria | Death, repeat revascularization† | Death, nonfatal MI, clinical TLR | Death, nonfatal MI, repeat revascularization† |