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Table 2 Study characteristics

From: Does intravascular ultrasound provide clinical benefits for percutaneous coronary intervention with bare-metal stent implantation? A meta-analysis of randomized controlled trials

Study DIPOL AVID RESIST TULIP OPTICUS
Enrolling years 2000 to 2002 1995 to 1998 1995 to 1997 1991 to 2001 1996 to 1998
Randomized Yes Yes Yes Yes Yes
- Blinded? Yes Yes N/A N/A Yes
- When? Pre-intervention Pre-intervention Post-intervention Pre-intervention Pre-intervention
Intention-to-treat analysis No Yes No Yes Yes
Exclusion criteria
- Long lesions Yes (> 25 mm) No Yes (> 15 mm) No Yes (> 25 mm)
- Bifurcation Yes No No Yes Yes
- Left main coronary artery Yes Yes No No Yes
- Chronic total occlusion Yes Yes Yes Yes No
- Recent acute coronary syndrome Yes No (except MI with TIMI flow grade < 3) Yes Yes Yes
- Small vessels Yes (≤ 2.75 mm) Yes (< 2.5 mm) Yes (< 3 mm) Yes (< 3 mm) Yes (< 2.5 mm)
- Others Age < 18 and > 70 y; extensive calcification; saphenous vein graft lesions Age < 18 y; non-covered dissection; large vessels (> 3.25 mm) Previous CABG Focal (< 20 mm) or ostial lesions  
Pre-intervention IVUS Yes No No Yes Yes
Post-intervention IVUS Yes Yes Yes Yes Yes
PCI success criteria Stent CSA/average CSA > 80%, complete apposition, stent CSA > 7.5 mm2 Stent CSA/distal CSA > 90%, complete apposition, no dissection Stent CSA/average CSA > 80% Stent MLD/average MLD > 80%, complete apposition, stent CSA ≥ distal CSA Stenosis < 10% and MUSIC study criteria [10]
- PCI success by IVUS,% 96 63 61 89 82.2 and 56 (MUSIC)
Clinical follow-up, months 6 12 18 12 12
Angiographic follow-up, months 6*   6 (com USIC) 6 6
MACE Death, nonfatal MI, repeat revascularization Without explicit criteria Death, repeat revascularization Death, nonfatal MI, clinical TLR Death, nonfatal MI, repeat revascularization
  1. *Angiographic follow-up was left to the discretion of the operator: 87.9% (IVUS-guided group) and 83.7% (angio-guided group). CABG or repeat PCI for any reason. IVUS, interventional ultrasound; PCI, percutaneous coronary intervention; MACE, major adverse cardiovascular events; CSA, cross sectional area; MI, myocardial infarction; TIMI, thrombolysis in myocardial infarction; CABG, coronary artery bypass graft; MLD, minimum lumen diameter; clinical TLR, ischemia-driven target lesion revascularization.