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Table 4 The effective sample sizes and corresponding information fractions and power estimates from the four comparisons of newer treatments vs. low-dose NRT

From: Sample size and power considerations in network meta-analysis

Comparison (vs. low-dose NRT) Effective head-to-head sample size Effective indirect sample size Total effective sample size Information fraction Statistical power Statistical power to detect observed improvement* Network meta-analysis odds ratio estimate (95% credible interval)
Combination NRT 1,664 1,691 3,355 53% 66% - 1.05 (0.76 – 1.41)
High-dose NRT 3,605 2,211 5,816 92% 88% >99% 1.32 (1.11 – 1.57)
Buproprion - 7,707 7,707 >100% 95% - 0.99 (0.86 – 1.14)
Varenicline 720 3,625 4,268 68% 76% >99% 1.38 (1.15 – 1.64)