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Table 2 Effective heterogeneity-corrected sample sizes of indirect comparison scenarios with varying degrees of patient count ratios and heterogeneity in each comparison (A vs. C and B vs. C), but with fixed total sample size of 10,000

From: Sample size and power considerations in network meta-analysis

Patient ratio Precision ratio IAC 2 IBC 2 I2 adjusted precision ratio Effective sample size
5,000:5,000 (1:1) 4.00 0% 0% 4.00 2,500
   0% 25% 4.60 2,188
   0% 50% 5.33 1,875
   25% 50% 6.40 1,563
   50% 50% 8.00 1,250
3,333:6,667 (1:2) 4.50 0% 0% 4.50 2,222
   0% 25% 5.40 1,852
   0% 50% 6.75 1,481
   25% 0% 4.91 2,037
   25% 25% 6.00 1,667
   25% 50% 7.72 1,296
   50% 0% 5.40 1,852
   50% 25% 6.75 1,482
   50% 50% 9.00 1,111
2,500:7,500 (1:3) 5.33 0% 0% 5.33 1,876
   0% 25% 6.56 1,524
   0% 50% 8.53 1,173
   25% 0% 5.69 1,759
   25% 25% 7.11 1,407
   25% 50% 9.48 1,055
   50% 0% 6.09 1,642
   50% 25% 7.75 1,290
   50% 50% 10.7 938
2,000:8,000 (1:4) 6.25 0% 0% 6.25 1,600
   0% 25% 7.81 1,280
   0% 50% 10.4 960
   25% 0% 6.58 1,520
   25% 25% 8.33 1,200
   25% 50% 11.4 880
   50% 0% 6.94 1,440
   50% 25% 8.93 1,120
   50% 50% 12.5 800
1,667:8,333 (1:5) 7.20 0% 0% 7.20 1,389
   0% 25% 9.09 1,100
   0% 50% 12.4 810
   25% 0% 7.51 1,331
   25% 25% 9.60 1,042
   25% 50% 13.3 752
   50% 0% 7.86 1,273
   50% 25% 10.2 984
   50% 50% 14.4 694
1,000:9,000 (1:9) 11.11 0% 0% 11.1 900
   0% 25% 14.3 698
   0% 50% 20.2 495
   25% 0% 11.4 878
   25% 25% 14.8 675
   25% 50% 21.1 473
   50% 0% 11.7 855
   50% 25% 15.3 653
   50% 50% 22.2 450