From: A protocol for a systematic review for perioperative pregabalin use
Type of outcome | Outcome |
---|---|
Primary perioperative efficacy outcomes | · Pain relief at rest and on movement (any measure) |
· Reduction in postoperative opioid and other analgesic consumption (dose, frequency, and time of first use of rescue analgesia) | |
Secondary perioperative and long-term outcomes | · Postoperative nausea and vomiting |
· Anxiolysis | |
· Sleep restoration | |
· Early ambulation | |
· Early feeding | |
· Length of hospital stay | |
· Chronic postoperative pain | |
Perioperative harms outcomes | · Somnolence |
· Sedation | |
· Visual disturbances | |
· Confusion | |
· Respiratory depression | |
· Cognitive dysfunction | |
· Withdrawal due to adverse events | |
· Participants with at least one serious adverse event (as defined by the FDA) | |
· Mortality | |
· Participants with at least one adverse event | |
· Withdrawal due to lack of pregabalin efficacy | |
FDA: Food and Drugs Administration |