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Table 6 Minimum O2 saturation (%) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study
PMID
Baseline AHI (SD)
[eligibility]
Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change
(final)
Net difference
or difference
95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32]
11035671
58 (6)
[≥10]
12.7 (5.3) 2 months
(XO)
APAP 25 66.5
(13.6)
85.2 -1.4 nd nd 0 B
     CPAP 25 66.5
(13.6)
86.6      
Galetke 2008 [12]
17148931
33 (19)
[> 10]
10.3 (5.7) 2 months
(XO)
APAP 20 77.8 (8.4) 8.7 -1.8 -3.8 to 0.2 nd nd C
     CPAP 20 77.8 (8.4) 10.5      
Hussain 2004 [20]
15072173
47 (36)
[> 15]
11.1 (6.4) 1 month
(XO)
APAP 10 67.8 (12.5) 14 -3.9 -7.3 to -0.5 nd 0 C
     CPAP 10 67.8 (12.5) 17.9      
Konermann 1998 [31]
9515848
38 (14)
[> 20}
nd 3 to 6 months
(PL)
APAP 25 76.5 (12.4) 90.3 1.1 nd NS 4 B
     CPAP 23 74.5
(10.7)
87.2      
Meurice 2007 [13]
17638595
55 (10)
[nd]
11.8 (4.9) 6 months
(PL)
APAP (AutoSet) 15 82.1 (12.8) 0.2 -2.9 -7.1 to 7.5 nd 15 B
     CPAP 14 82.3
(9.9)
0.5      
Nolan 2007 [14]
17326544
15 (8)
[≥5)
12.3 (4) 2 months
(XO)
APAP 29 79 (11.5) 8.5 4.8 -7.4 to 17.0b 0.44 15 B
     CPAP 29 79 (11.5) 3.7      
Patruno 2007 [16] 17494789 46 (14)
[> 20]
15 (2.7) 3 months
(PL)
APAP 15 71.7 (10.6) 16.4 -4.4 -11.8 to 3.0 nd 23 C
     CPAP 16 70.0
(11.7)
20.8      
Randerath 2001 [26]
11254519
35 (26)
[≥10]
11.1 (5.1) 1.5 months
(XO)
APAP 52 81 (8.0) 7.0 -1.0 -2.1 to 0.1 nd 12 B
     CPAP 52 81 (8.0) 8.0      
Resta 2004 [24]
15679008
47 (11)
[> 30]
13.9 (3.2) 1 month
(PL)
APAP 10 72.4 (10.5) 15.9 0.9 -7.4 to 9.2 nd 0 C
     CPAP 10 74.1 (10.8) 15.0      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value.