Skip to main content

Advertisement

Table 6 Minimum O2 saturation (%) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Baseline AHI (SD) [eligibility] Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change (final) Net difference or difference 95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32] 11035671 58 (6) [≥10] 12.7 (5.3) 2 months (XO) APAP 25 66.5 (13.6) 85.2 -1.4 nd nd 0 B
     CPAP 25 66.5 (13.6) 86.6      
Galetke 2008 [12] 17148931 33 (19) [> 10] 10.3 (5.7) 2 months (XO) APAP 20 77.8 (8.4) 8.7 -1.8 -3.8 to 0.2 nd nd C
     CPAP 20 77.8 (8.4) 10.5      
Hussain 2004 [20] 15072173 47 (36) [> 15] 11.1 (6.4) 1 month (XO) APAP 10 67.8 (12.5) 14 -3.9 -7.3 to -0.5 nd 0 C
     CPAP 10 67.8 (12.5) 17.9      
Konermann 1998 [31] 9515848 38 (14) [> 20} nd 3 to 6 months (PL) APAP 25 76.5 (12.4) 90.3 1.1 nd NS 4 B
     CPAP 23 74.5 (10.7) 87.2      
Meurice 2007 [13] 17638595 55 (10) [nd] 11.8 (4.9) 6 months (PL) APAP (AutoSet) 15 82.1 (12.8) 0.2 -2.9 -7.1 to 7.5 nd 15 B
     CPAP 14 82.3 (9.9) 0.5      
Nolan 2007 [14] 17326544 15 (8) [≥5) 12.3 (4) 2 months (XO) APAP 29 79 (11.5) 8.5 4.8 -7.4 to 17.0b 0.44 15 B
     CPAP 29 79 (11.5) 3.7      
Patruno 2007 [16] 17494789 46 (14) [> 20] 15 (2.7) 3 months (PL) APAP 15 71.7 (10.6) 16.4 -4.4 -11.8 to 3.0 nd 23 C
     CPAP 16 70.0 (11.7) 20.8      
Randerath 2001 [26] 11254519 35 (26) [≥10] 11.1 (5.1) 1.5 months (XO) APAP 52 81 (8.0) 7.0 -1.0 -2.1 to 0.1 nd 12 B
     CPAP 52 81 (8.0) 8.0      
Resta 2004 [24] 15679008 47 (11) [> 30] 13.9 (3.2) 1 month (PL) APAP 10 72.4 (10.5) 15.9 0.9 -7.4 to 9.2 nd 0 C
     CPAP 10 74.1 (10.8) 15.0      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value.