Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Table 6 Minimum O₂ saturation (%) in randomized controlled trials of APAP versus CPAP

Study PMID	Baseline AHI (SD) [eligibility]	Baseline ESS (SD)	Duration (design)	Interventions	Number analyzed	Baseline (SD)	Change (final)	Net difference or difference	95% CI^a	P	Dropout (%)	Study quality
d'Ortho 2000 [32] 11035671	58 (6) [≥10]	12.7 (5.3)	2 months (XO)	APAP	25	66.5 (13.6)	85.2	-1.4	nd	nd	0	B
				CPAP	25	66.5 (13.6)	86.6
Galetke 2008 [12] 17148931	33 (19) [> 10]	10.3 (5.7)	2 months (XO)	APAP	20	77.8 (8.4)	8.7	-1.8	-3.8 to 0.2	nd	nd	C
				CPAP	20	77.8 (8.4)	10.5
Hussain 2004 [20] 15072173	47 (36) [> 15]	11.1 (6.4)	1 month (XO)	APAP	10	67.8 (12.5)	14	-3.9	-7.3 to -0.5	nd	0	C
				CPAP	10	67.8 (12.5)	17.9
Konermann 1998 [31] 9515848	38 (14) [> 20}	nd	3 to 6 months (PL)	APAP	25	76.5 (12.4)	90.3	1.1	nd	NS	4	B
				CPAP	23	74.5 (10.7)	87.2
Meurice 2007 [13] 17638595	55 (10) [nd]	11.8 (4.9)	6 months (PL)	APAP (AutoSet)	15	82.1 (12.8)	0.2	-2.9	-7.1 to 7.5	nd	15	B
				CPAP	14	82.3 (9.9)	0.5
Nolan 2007 [14] 17326544	15 (8) [≥5)	12.3 (4)	2 months (XO)	APAP	29	79 (11.5)	8.5	4.8	-7.4 to 17.0^b	0.44	15	B
				CPAP	29	79 (11.5)	3.7
Patruno 2007 [16] 17494789	46 (14) [> 20]	15 (2.7)	3 months (PL)	APAP	15	71.7 (10.6)	16.4	-4.4	-11.8 to 3.0	nd	23	C
				CPAP	16	70.0 (11.7)	20.8
Randerath 2001 [26] 11254519	35 (26) [≥10]	11.1 (5.1)	1.5 months (XO)	APAP	52	81 (8.0)	7.0	-1.0	-2.1 to 0.1	nd	12	B
				CPAP	52	81 (8.0)	8.0
Resta 2004 [24] 15679008	47 (11) [> 30]	13.9 (3.2)	1 month (PL)	APAP	10	72.4 (10.5)	15.9	0.9	-7.4 to 9.2	nd	0	C
				CPAP	10	74.1 (10.8)	15.0

AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. ^aEstimated from reported data. ^bEstimated from reported P value.

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