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Table 4 ESS in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study

PMID

Baseline AHI (SD)

[eligibility]

Baseline ESS (SD)

Duration (design)

Interventions

Number analyzed

Baseline (SD)

Change

(final)

Net difference

or difference

95% CIa

P

Dropout (%)

Study quality

d'Ortho 2000 [32]

11035671

58 (6)

[≥10]

12.7 (5.3)

2 months

(XO)

APAP

25

12.7 (5.3)

-3.4

0.1

nd

NS

0

B

    

CPAP

25

12.7

(5.3)

-3.5

     

Damjanovic 2009 [10]

19129293

44 (25)

[≥15]

8.8 (5.2)

3 months

(PL)

APAP

46

8.5 (5.4)

-2.6

-0.3

-2.32 to 1.72

nd

8

B

    

CPAP

46

9.3 (4.8)

-2.3

     
   

9 months

(PL)

APAP

34

8.5 (5.4)

-2.6

0.1

-1.92 to 2.12

nd

22

 
    

CPAP

44

9.3 (4.8)

-2.7

     

Fietze 2007 [11]

17337881

42 (26)

[≥10]

nd

1.5 months

(PL)

APAP

20

nd

nd

nd

nd

NS

0

C

    

CPAP

21

nd

nd

     

Galetke 2008 [12]

17148931

33 (19)

[> 10]

10.3 (5.7)

2 months

(XO)

APAP

20

10.3 (5.7)

-5.4

-1.7

-3.76 to 0.36

nd

0

C

    

CPAP

20

10.3 (5.7)

-3.7

     

Hudgel 2000 [18]

10947032

30 (25)

[nd]

16.0 (5.0)

3 months

(XO)

APAP

39

16.0 (5.0)

-7.0

1

-0.96 to 2.96

nd

35

C

    

CPAP

39

16.0 (5.0)

-8.0

     

Hussain 2004 [20] 15072173

47 (36)

[> 15]

11.1 (6.4)

1 months

(XO)

APAP

10

11.1 (6.4)

-3.1

1.4

-2.2 to 5.0

nd

0

C

    

CPAP

10

11.1 (6.4)

-4.5

     

Hukins 2004 [19]

15683142

56 (nd)

[≥5]

12.5 (nd)

1 to 2 months

(XO)

APAP

46

12.5 (nd)

-4.5

-0.2

nd

NS

16

B

    

CPAP

46

12.5 (nd)

-4.3

     

Marrone 2004 [21]

15165530

68 (12)

[30]

16.3 (5.0)

1 month

(XO)

APAP

22

16.3 (5.0)

-12.4

-1

-2.4 to 0.4

nd

0

C

    

CPAP

22

16.3 (5.0)

-11.4

     

Massie 2003 [22]

12406840

nd

[≥15]

nd

1.5 months

(XO)

APAP

44

nd

nd

-1

-2.06 to 0.06b

0.065

4

B

    

CPAP

44

nd

nd

     

Meurice 2007 [13]

17638595

55 (10)

[nd]

11.8 (4.9)

3 months

(PL)

APAP (AutoSet)

15

12.9 (4.3)

-9.1

-3.3

-6.68 to 0.08

NS

15

B

    

CPAP

14

10.6 (5.2)

-5.8

     
   

6 months

(PL)

APAP (AutoSet)

15

12.9 (4.3)

-7.7

-3.0

-6.44 to 0.44

NS

15

 
    

CPAP

14

10.6 (5.2)

-4.7

     

Nolan 2007 [14]

17326544

15 (8)

[≥5)

12.3 (4.0)

2 months

(XO)

APAP

29

12.3 (4.0)

-3.7

0.9

-0.99 to 2.79b

0.35

15

B

    

CPAP

29

12.3 (4.0)

-4.6

     

Noseda 2004 [23]

15249439

nd [> 20]

10.7 (2.4)

2 months

(XO)

APAP

24

10.7 (2.4)

nd

-1

-1.76 to -0.24b

< 0.01

11

B

    

CPAP

24

10.7 (2.4)

nd

     

Nussbaumer 2006 [15]

16537862

41 (20)

[> 10]

12.7 (3.29)

1 month

(XO)

APAP

30

12.7

(0.6)

-6.6

0

-1.6 to 1.1

nd

12

B

    

CPAP

30

12.7

(0.6)

-6.6

     

Patruno 2007 [16]

17494789

46 (14)

[> 20]

15 (2.7)

3 months

(PL)

APAP

15

15.8 (3.5)

nd

nd

nd

NS

23

C

    

CPAP

16

14.1 (1.7)

nd

     

Planes 2003 [29]

12683473

59 (17)

[≥30]

15.1 (3.9)

2 months

(PL)

APAP

16

15.5 (4.7)

-8.0

-0.9

-3.72 to 1.92

nd

14

 
    

CPAP

14

14.7 (3.9)

-7.1

     

Randerath 2001 [26]

11254519

35 (26)

[≥10]

11.1 (5.1)

1.5 months

(XO)

APAP

52

11.1 (5.1)

-3.3

-1

-2.26 to 0.26

nd

12

B

    

CPAP

52

11.1 (5.1)

-2.3

     

Resta 2004 [24]

15679008

47 (11)

[> 30]

13.9 (3.2)

1 month

(PL)

APAP

10

15.7 (5.1)

-10.5

-2.6

-5.84 to 0.64

nd

0

C

    

CPAP

10

12.0

(3.2)

-7.9

     

Senn 2003 [25]

Switzerland

14525804

46 (23)

[> 10]

14.2 (3.77)

1 month

(XO)

APAP (Autoset T)

29

14.2 (3.77)

-5.2

0.8

-0.49 to 2.09

nd

7

B

    

APAP (AutoAdjust)

29

14.2 (3.77)

-6.2

-0.2

-1.68 to 1.28

nd

  
    

CPAP

29

14.2 (3.77)

-6.0

     

Sériès 1997 [27]

9341056

44 (20)

[nd]

15.5 (4.5)

0.75 months

(PL)

APAPc

12

17.0

(4.1)

-9.1

-0.8

-4.28 to 2.69

nd

0

C

    

CPAP

12

16.1 (4.5)

-8.3

     
    

APAPd

12

13.5

(4.7)

-6.5

1.8

-1.78 to 5.38

nd

  
    

CPAP

12

16.1

(4.5)

-8.3

     

To 2008 [17]

18197915

54 (nd)

[> 30]

13.4 (nd)

1 month

(XO)

APAP

41

13.4 (5.76)

-4.9

0.3

-1.46 to 2.06

nd

5

B

    

CPAP

41

13.4 (5.76)

-5.2

     
   

2 months

(XO)

APAP

41

13.4 (5.76)

-4.9

0

-1.76 to 1.76

nd

  
    

CPAP

41

13.4 (5.76)

-4.9

     

Vennelle 2010 [30]

20175411

33 (18) [≥15]

14 (3)

6 weeks (XO)

APAP

181

14 (3)

-4.5

-0.5

-0.95 to -0.05

0.031

9.5

A

    

CPAP

181

14 (3)

-4

     

West 2006 [33]

33e (nd)

[> 10]

16.5f(nd)

1 month

(PL)

APAP

29

16 (median)

7 (final)

  

0.9

6.1

A

    

CPAP (auto)

31

17 (median)

7 (final)

     
    

CPAP (algo)

32

16.5

(median)

6 (final)

     
   

6 months

(PL)

APAP

28

16 (median)

6 (final)

  

0.8

9.2

 
    

CPAP (auto)

31

17 (median)

5 (final)

     
    

CPAP (algo)

27

16.5

(median)

5 (final)

     
  1. AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dMeasured effective pressure. e> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm. fMedian in algorithm-determined CPAP arm.
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Systematic Reviews

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