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Table 4 ESS in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Baseline AHI (SD) [eligibility] Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change (final) Net difference or difference 95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32] 11035671 58 (6) [≥10] 12.7 (5.3) 2 months (XO) APAP 25 12.7 (5.3) -3.4 0.1 nd NS 0 B
     CPAP 25 12.7 (5.3) -3.5      
Damjanovic 2009 [10] 19129293 44 (25) [≥15] 8.8 (5.2) 3 months (PL) APAP 46 8.5 (5.4) -2.6 -0.3 -2.32 to 1.72 nd 8 B
     CPAP 46 9.3 (4.8) -2.3      
    9 months (PL) APAP 34 8.5 (5.4) -2.6 0.1 -1.92 to 2.12 nd 22  
     CPAP 44 9.3 (4.8) -2.7      
Fietze 2007 [11] 17337881 42 (26) [≥10] nd 1.5 months (PL) APAP 20 nd nd nd nd NS 0 C
     CPAP 21 nd nd      
Galetke 2008 [12] 17148931 33 (19) [> 10] 10.3 (5.7) 2 months (XO) APAP 20 10.3 (5.7) -5.4 -1.7 -3.76 to 0.36 nd 0 C
     CPAP 20 10.3 (5.7) -3.7      
Hudgel 2000 [18] 10947032 30 (25) [nd] 16.0 (5.0) 3 months (XO) APAP 39 16.0 (5.0) -7.0 1 -0.96 to 2.96 nd 35 C
     CPAP 39 16.0 (5.0) -8.0      
Hussain 2004 [20] 15072173 47 (36) [> 15] 11.1 (6.4) 1 months (XO) APAP 10 11.1 (6.4) -3.1 1.4 -2.2 to 5.0 nd 0 C
     CPAP 10 11.1 (6.4) -4.5      
Hukins 2004 [19] 15683142 56 (nd) [≥5] 12.5 (nd) 1 to 2 months (XO) APAP 46 12.5 (nd) -4.5 -0.2 nd NS 16 B
     CPAP 46 12.5 (nd) -4.3      
Marrone 2004 [21] 15165530 68 (12) [30] 16.3 (5.0) 1 month (XO) APAP 22 16.3 (5.0) -12.4 -1 -2.4 to 0.4 nd 0 C
     CPAP 22 16.3 (5.0) -11.4      
Massie 2003 [22] 12406840 nd [≥15] nd 1.5 months (XO) APAP 44 nd nd -1 -2.06 to 0.06b 0.065 4 B
     CPAP 44 nd nd      
Meurice 2007 [13] 17638595 55 (10) [nd] 11.8 (4.9) 3 months (PL) APAP (AutoSet) 15 12.9 (4.3) -9.1 -3.3 -6.68 to 0.08 NS 15 B
     CPAP 14 10.6 (5.2) -5.8      
    6 months (PL) APAP (AutoSet) 15 12.9 (4.3) -7.7 -3.0 -6.44 to 0.44 NS 15  
     CPAP 14 10.6 (5.2) -4.7      
Nolan 2007 [14] 17326544 15 (8) [≥5) 12.3 (4.0) 2 months (XO) APAP 29 12.3 (4.0) -3.7 0.9 -0.99 to 2.79b 0.35 15 B
     CPAP 29 12.3 (4.0) -4.6      
Noseda 2004 [23] 15249439 nd [> 20] 10.7 (2.4) 2 months (XO) APAP 24 10.7 (2.4) nd -1 -1.76 to -0.24b < 0.01 11 B
     CPAP 24 10.7 (2.4) nd      
Nussbaumer 2006 [15] 16537862 41 (20) [> 10] 12.7 (3.29) 1 month (XO) APAP 30 12.7 (0.6) -6.6 0 -1.6 to 1.1 nd 12 B
     CPAP 30 12.7 (0.6) -6.6      
Patruno 2007 [16] 17494789 46 (14) [> 20] 15 (2.7) 3 months (PL) APAP 15 15.8 (3.5) nd nd nd NS 23 C
     CPAP 16 14.1 (1.7) nd      
Planes 2003 [29] 12683473 59 (17) [≥30] 15.1 (3.9) 2 months (PL) APAP 16 15.5 (4.7) -8.0 -0.9 -3.72 to 1.92 nd 14  
     CPAP 14 14.7 (3.9) -7.1      
Randerath 2001 [26] 11254519 35 (26) [≥10] 11.1 (5.1) 1.5 months (XO) APAP 52 11.1 (5.1) -3.3 -1 -2.26 to 0.26 nd 12 B
     CPAP 52 11.1 (5.1) -2.3      
Resta 2004 [24] 15679008 47 (11) [> 30] 13.9 (3.2) 1 month (PL) APAP 10 15.7 (5.1) -10.5 -2.6 -5.84 to 0.64 nd 0 C
     CPAP 10 12.0 (3.2) -7.9      
Senn 2003 [25] Switzerland 14525804 46 (23) [> 10] 14.2 (3.77) 1 month (XO) APAP (Autoset T) 29 14.2 (3.77) -5.2 0.8 -0.49 to 2.09 nd 7 B
     APAP (AutoAdjust) 29 14.2 (3.77) -6.2 -0.2 -1.68 to 1.28 nd   
     CPAP 29 14.2 (3.77) -6.0      
Sériès 1997 [27] 9341056 44 (20) [nd] 15.5 (4.5) 0.75 months (PL) APAPc 12 17.0 (4.1) -9.1 -0.8 -4.28 to 2.69 nd 0 C
     CPAP 12 16.1 (4.5) -8.3      
     APAPd 12 13.5 (4.7) -6.5 1.8 -1.78 to 5.38 nd   
     CPAP 12 16.1 (4.5) -8.3      
To 2008 [17] 18197915 54 (nd) [> 30] 13.4 (nd) 1 month (XO) APAP 41 13.4 (5.76) -4.9 0.3 -1.46 to 2.06 nd 5 B
     CPAP 41 13.4 (5.76) -5.2      
    2 months (XO) APAP 41 13.4 (5.76) -4.9 0 -1.76 to 1.76 nd   
     CPAP 41 13.4 (5.76) -4.9      
Vennelle 2010 [30] 20175411 33 (18) [≥15] 14 (3) 6 weeks (XO) APAP 181 14 (3) -4.5 -0.5 -0.95 to -0.05 0.031 9.5 A
     CPAP 181 14 (3) -4      
West 2006 [33] 33e (nd) [> 10] 16.5f(nd) 1 month (PL) APAP 29 16 (median) 7 (final)    0.9 6.1 A
     CPAP (auto) 31 17 (median) 7 (final)      
     CPAP (algo) 32 16.5 (median) 6 (final)      
    6 months (PL) APAP 28 16 (median) 6 (final)    0.8 9.2  
     CPAP (auto) 31 17 (median) 5 (final)      
     CPAP (algo) 27 16.5 (median) 5 (final)      
  1. AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dMeasured effective pressure. e> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm. fMedian in algorithm-determined CPAP arm.