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Table 4 ESS in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study
PMID
Baseline AHI (SD)
[eligibility]
Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change
(final)
Net difference
or difference
95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32]
11035671
58 (6)
[≥10]
12.7 (5.3) 2 months
(XO)
APAP 25 12.7 (5.3) -3.4 0.1 nd NS 0 B
     CPAP 25 12.7
(5.3)
-3.5      
Damjanovic 2009 [10]
19129293
44 (25)
[≥15]
8.8 (5.2) 3 months
(PL)
APAP 46 8.5 (5.4) -2.6 -0.3 -2.32 to 1.72 nd 8 B
     CPAP 46 9.3 (4.8) -2.3      
    9 months
(PL)
APAP 34 8.5 (5.4) -2.6 0.1 -1.92 to 2.12 nd 22  
     CPAP 44 9.3 (4.8) -2.7      
Fietze 2007 [11]
17337881
42 (26)
[≥10]
nd 1.5 months
(PL)
APAP 20 nd nd nd nd NS 0 C
     CPAP 21 nd nd      
Galetke 2008 [12]
17148931
33 (19)
[> 10]
10.3 (5.7) 2 months
(XO)
APAP 20 10.3 (5.7) -5.4 -1.7 -3.76 to 0.36 nd 0 C
     CPAP 20 10.3 (5.7) -3.7      
Hudgel 2000 [18]
10947032
30 (25)
[nd]
16.0 (5.0) 3 months
(XO)
APAP 39 16.0 (5.0) -7.0 1 -0.96 to 2.96 nd 35 C
     CPAP 39 16.0 (5.0) -8.0      
Hussain 2004 [20] 15072173 47 (36)
[> 15]
11.1 (6.4) 1 months
(XO)
APAP 10 11.1 (6.4) -3.1 1.4 -2.2 to 5.0 nd 0 C
     CPAP 10 11.1 (6.4) -4.5      
Hukins 2004 [19]
15683142
56 (nd)
[≥5]
12.5 (nd) 1 to 2 months
(XO)
APAP 46 12.5 (nd) -4.5 -0.2 nd NS 16 B
     CPAP 46 12.5 (nd) -4.3      
Marrone 2004 [21]
15165530
68 (12)
[30]
16.3 (5.0) 1 month
(XO)
APAP 22 16.3 (5.0) -12.4 -1 -2.4 to 0.4 nd 0 C
     CPAP 22 16.3 (5.0) -11.4      
Massie 2003 [22]
12406840
nd
[≥15]
nd 1.5 months
(XO)
APAP 44 nd nd -1 -2.06 to 0.06b 0.065 4 B
     CPAP 44 nd nd      
Meurice 2007 [13]
17638595
55 (10)
[nd]
11.8 (4.9) 3 months
(PL)
APAP (AutoSet) 15 12.9 (4.3) -9.1 -3.3 -6.68 to 0.08 NS 15 B
     CPAP 14 10.6 (5.2) -5.8      
    6 months
(PL)
APAP (AutoSet) 15 12.9 (4.3) -7.7 -3.0 -6.44 to 0.44 NS 15  
     CPAP 14 10.6 (5.2) -4.7      
Nolan 2007 [14]
17326544
15 (8)
[≥5)
12.3 (4.0) 2 months
(XO)
APAP 29 12.3 (4.0) -3.7 0.9 -0.99 to 2.79b 0.35 15 B
     CPAP 29 12.3 (4.0) -4.6      
Noseda 2004 [23]
15249439
nd [> 20] 10.7 (2.4) 2 months
(XO)
APAP 24 10.7 (2.4) nd -1 -1.76 to -0.24b < 0.01 11 B
     CPAP 24 10.7 (2.4) nd      
Nussbaumer 2006 [15]
16537862
41 (20)
[> 10]
12.7 (3.29) 1 month
(XO)
APAP 30 12.7
(0.6)
-6.6 0 -1.6 to 1.1 nd 12 B
     CPAP 30 12.7
(0.6)
-6.6      
Patruno 2007 [16]
17494789
46 (14)
[> 20]
15 (2.7) 3 months
(PL)
APAP 15 15.8 (3.5) nd nd nd NS 23 C
     CPAP 16 14.1 (1.7) nd      
Planes 2003 [29]
12683473
59 (17)
[≥30]
15.1 (3.9) 2 months
(PL)
APAP 16 15.5 (4.7) -8.0 -0.9 -3.72 to 1.92 nd 14  
     CPAP 14 14.7 (3.9) -7.1      
Randerath 2001 [26]
11254519
35 (26)
[≥10]
11.1 (5.1) 1.5 months
(XO)
APAP 52 11.1 (5.1) -3.3 -1 -2.26 to 0.26 nd 12 B
     CPAP 52 11.1 (5.1) -2.3      
Resta 2004 [24]
15679008
47 (11)
[> 30]
13.9 (3.2) 1 month
(PL)
APAP 10 15.7 (5.1) -10.5 -2.6 -5.84 to 0.64 nd 0 C
     CPAP 10 12.0
(3.2)
-7.9      
Senn 2003 [25]
Switzerland
14525804
46 (23)
[> 10]
14.2 (3.77) 1 month
(XO)
APAP (Autoset T) 29 14.2 (3.77) -5.2 0.8 -0.49 to 2.09 nd 7 B
     APAP (AutoAdjust) 29 14.2 (3.77) -6.2 -0.2 -1.68 to 1.28 nd   
     CPAP 29 14.2 (3.77) -6.0      
Sériès 1997 [27]
9341056
44 (20)
[nd]
15.5 (4.5) 0.75 months
(PL)
APAPc 12 17.0
(4.1)
-9.1 -0.8 -4.28 to 2.69 nd 0 C
     CPAP 12 16.1 (4.5) -8.3      
     APAPd 12 13.5
(4.7)
-6.5 1.8 -1.78 to 5.38 nd   
     CPAP 12 16.1
(4.5)
-8.3      
To 2008 [17]
18197915
54 (nd)
[> 30]
13.4 (nd) 1 month
(XO)
APAP 41 13.4 (5.76) -4.9 0.3 -1.46 to 2.06 nd 5 B
     CPAP 41 13.4 (5.76) -5.2      
    2 months
(XO)
APAP 41 13.4 (5.76) -4.9 0 -1.76 to 1.76 nd   
     CPAP 41 13.4 (5.76) -4.9      
Vennelle 2010 [30]
20175411
33 (18) [≥15] 14 (3) 6 weeks (XO) APAP 181 14 (3) -4.5 -0.5 -0.95 to -0.05 0.031 9.5 A
     CPAP 181 14 (3) -4      
West 2006 [33] 33e (nd)
[> 10]
16.5f(nd) 1 month
(PL)
APAP 29 16 (median) 7 (final)    0.9 6.1 A
     CPAP (auto) 31 17 (median) 7 (final)      
     CPAP (algo) 32 16.5
(median)
6 (final)      
    6 months
(PL)
APAP 28 16 (median) 6 (final)    0.8 9.2  
     CPAP (auto) 31 17 (median) 5 (final)      
     CPAP (algo) 27 16.5
(median)
5 (final)      
  1. AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dMeasured effective pressure. e> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm. fMedian in algorithm-determined CPAP arm.