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Table 3 AHI (events/hour) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study

PMID

Baseline AHI (SD)

[eligibility]

Baseline ESS (SD)

Duration (design)

Interventions

Number analyzed

Baseline (SD)

Change

(final)

Net difference

or difference

95% CIa

P

Dropout (%)

Study quality

d'Ortho 2000 [32]

11035671

58 (6)

[≥10]

12.7 (5.3)

2 months

(XO)

APAP

25

57.8 (5.8)

-47.2

0.9

nd

NS

0

B

    

CPAP

25

57.8

(5.8)

-48.1

     

Damjanovic 2009 [10]

19129293

44 (25)

[≥15]

8.8 (5.2)

3 months

(PL)

APAP

46

41.8 (23.7)

-37.0

1.8

-7.14 to 10.74

nd

8

B

    

CPAP

46

45.5 (24.4)

-38.8

     
   

9 months

(PL)

APAP

34

41.8 (23.7)

-38.2

1.9

-6.86 to 10.66

nd

22

 
    

CPAP

44

45.5 (24.4)

-40.1

     

Fietze 2007 [11]

17337881

42 (26)

[≥10]

nd

1.5 months

(PL)

APAP

20

43.3 (30.2)

-38.9

0.5

-1.19 to 2.19

nd

0

C

    

CPAP

21

40.4 (26.1)

-36.5

     

Galetke 2008 [12]

17148931

33 (19)

[> 10]

10.3 (5.7)

2 months

(XO)

APAP

20

32.9 (19.1)

-27.3

1.0

-0.45 to 2.45

nd

nd

C

    

CPAP

20

32.9 (19.1)

-28.3

     

Hussain 2004 [20]

15072173

47 (36)

[> 15]

11.1 (6.4)

1 month

(XO)

APAP

10

47.2 (35.6)

-34.1

3.5

-1.02 to 8.02

nd

0

C

    

CPAP

10

47.2 (35.6)

-37.6

     

Konermann 1998 [31]

9515848

38 (14)

[> 20]

nd

3 to 6 months

(PL)

APAP

25

35.5

(9.6)

-33.1

1.6

nd

NS

4

B

    

CPAP

23

38.3

(13.9)

-34.7

     

Massie 2003 [22]

12406840

nd

[≥15]

nd

1.5 months

(XO)

APAP

44

nd

nd

-1.1

-2.89 to 0.69

nd

4

B

    

CPAP

44

nd

nd

     

Meurice 2007 [13]

17638595

55 (10)

[nd]

11.8 (4.9)

6 months

(PL)

APAP (AutoSet)

15

53.4 (15.1)

-51.1

2.6

-8.88 to 14.08

nd

15

B

    

CPAP

14

56.1

(21.4)

-53.7

     

Nolan 2007 [14]

17326544

15 (8)

[≥5)

12.3 (4.0)

2 months

(XO)

APAP

29

14.7 (8)

-12.0

-0.8

-1.89 to 0.29b

0.15

15

B

    

CPAP

29

14.7 (8)

-11.2

     

Nussbaumer 2006 [15]

16537862

41 (20)

[> 10]

12.7 (3.3)

1 month

(XO)

APAP

30

41.1 (19.7)

-36.5

-0.8

-1.7 to 3.3c

nd

12

B

    

CPAP

30

41.2 (19.7)

-35.7

     

Patruno 2007 [16]

17494789

46 (14)

[> 20]

15 (2.7)

3 months

(PL)

APAP

15

47.3 (14.7)

-41.3

2.7

-7.01 to 12.41

nd

23

C

    

CPAP

16

46.0

(14.6)

-44.0

     

Planes 2003 [29]

12683473

59 (17)

[≥30]

15.1 (3.9)

2 months

(PL)

APAP

16

57.5 (16.5)

-49.9

0.7

-10.06 to 11.46

nd

14

C

    

CPAP

14

61.0

(17.4)

-50.6

     

Randerath 2001 [26]

11254519

35 (26)

[≥10]

11.1 (5.1)

1.5 months

(XO)

APAP

52

35.1 (26)

-30.1

0.7

-0.88 to 2.28

nd

12

B

    

CPAP

52

35.1 (26)

-30.8

     

Resta 2004 [24]

15679008

47 (11)

[> 30]

13.9 (3.2)

1 month

(PL)

APAP

10

48.0

(14.3)

-39.7

-2.8

-12.96 to 7.36

nd

0

C

    

CPAP

10

45.3 (10.7)

-36.9

     

Senn 2003 [25]

Switzerland

14525804

46 (23)

[> 10]

14.2 (3.8)

1 month

(XO)

APAP (Autoset T)

29

45.8 (22.6)

-39.8

0.7

-1.26 to 2.66

nd

7

B

    

APAP (AutoAdjust)

29

45.8 (22.6)

-38.1

2.4

-0.34 to 5.14

nd

  
    

CPAP

29

45.8

(22.6)

-40.5

     

Sériès 1997 [27]

9341056

44 (20)

[nd]

15.5 (4.5)

0.75 months

(PL)

APAPd

12

61.5 (27.9)

nde

-

-

NS

0

C

    

CPAP

12

50.1 (14.5)

nd

     
    

APAPf

12

46.8 (22.3)

nde

-

-

NS

  
    

CPAP

12

50.1 (14.5)

nd

     
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cActual reported data. dEstimated effective pressure. eDirections of changes not reported in the study. fMeasured effective pressure.