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Table 3 AHI (events/hour) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Baseline AHI (SD) [eligibility] Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change (final) Net difference or difference 95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32] 11035671 58 (6) [≥10] 12.7 (5.3) 2 months (XO) APAP 25 57.8 (5.8) -47.2 0.9 nd NS 0 B
     CPAP 25 57.8 (5.8) -48.1      
Damjanovic 2009 [10] 19129293 44 (25) [≥15] 8.8 (5.2) 3 months (PL) APAP 46 41.8 (23.7) -37.0 1.8 -7.14 to 10.74 nd 8 B
     CPAP 46 45.5 (24.4) -38.8      
    9 months (PL) APAP 34 41.8 (23.7) -38.2 1.9 -6.86 to 10.66 nd 22  
     CPAP 44 45.5 (24.4) -40.1      
Fietze 2007 [11] 17337881 42 (26) [≥10] nd 1.5 months (PL) APAP 20 43.3 (30.2) -38.9 0.5 -1.19 to 2.19 nd 0 C
     CPAP 21 40.4 (26.1) -36.5      
Galetke 2008 [12] 17148931 33 (19) [> 10] 10.3 (5.7) 2 months (XO) APAP 20 32.9 (19.1) -27.3 1.0 -0.45 to 2.45 nd nd C
     CPAP 20 32.9 (19.1) -28.3      
Hussain 2004 [20] 15072173 47 (36) [> 15] 11.1 (6.4) 1 month (XO) APAP 10 47.2 (35.6) -34.1 3.5 -1.02 to 8.02 nd 0 C
     CPAP 10 47.2 (35.6) -37.6      
Konermann 1998 [31] 9515848 38 (14) [> 20] nd 3 to 6 months (PL) APAP 25 35.5 (9.6) -33.1 1.6 nd NS 4 B
     CPAP 23 38.3 (13.9) -34.7      
Massie 2003 [22] 12406840 nd [≥15] nd 1.5 months (XO) APAP 44 nd nd -1.1 -2.89 to 0.69 nd 4 B
     CPAP 44 nd nd      
Meurice 2007 [13] 17638595 55 (10) [nd] 11.8 (4.9) 6 months (PL) APAP (AutoSet) 15 53.4 (15.1) -51.1 2.6 -8.88 to 14.08 nd 15 B
     CPAP 14 56.1 (21.4) -53.7      
Nolan 2007 [14] 17326544 15 (8) [≥5) 12.3 (4.0) 2 months (XO) APAP 29 14.7 (8) -12.0 -0.8 -1.89 to 0.29b 0.15 15 B
     CPAP 29 14.7 (8) -11.2      
Nussbaumer 2006 [15] 16537862 41 (20) [> 10] 12.7 (3.3) 1 month (XO) APAP 30 41.1 (19.7) -36.5 -0.8 -1.7 to 3.3c nd 12 B
     CPAP 30 41.2 (19.7) -35.7      
Patruno 2007 [16] 17494789 46 (14) [> 20] 15 (2.7) 3 months (PL) APAP 15 47.3 (14.7) -41.3 2.7 -7.01 to 12.41 nd 23 C
     CPAP 16 46.0 (14.6) -44.0      
Planes 2003 [29] 12683473 59 (17) [≥30] 15.1 (3.9) 2 months (PL) APAP 16 57.5 (16.5) -49.9 0.7 -10.06 to 11.46 nd 14 C
     CPAP 14 61.0 (17.4) -50.6      
Randerath 2001 [26] 11254519 35 (26) [≥10] 11.1 (5.1) 1.5 months (XO) APAP 52 35.1 (26) -30.1 0.7 -0.88 to 2.28 nd 12 B
     CPAP 52 35.1 (26) -30.8      
Resta 2004 [24] 15679008 47 (11) [> 30] 13.9 (3.2) 1 month (PL) APAP 10 48.0 (14.3) -39.7 -2.8 -12.96 to 7.36 nd 0 C
     CPAP 10 45.3 (10.7) -36.9      
Senn 2003 [25] Switzerland 14525804 46 (23) [> 10] 14.2 (3.8) 1 month (XO) APAP (Autoset T) 29 45.8 (22.6) -39.8 0.7 -1.26 to 2.66 nd 7 B
     APAP (AutoAdjust) 29 45.8 (22.6) -38.1 2.4 -0.34 to 5.14 nd   
     CPAP 29 45.8 (22.6) -40.5      
Sériès 1997 [27] 9341056 44 (20) [nd] 15.5 (4.5) 0.75 months (PL) APAPd 12 61.5 (27.9) nde - - NS 0 C
     CPAP 12 50.1 (14.5) nd      
     APAPf 12 46.8 (22.3) nde - - NS   
     CPAP 12 50.1 (14.5) nd      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cActual reported data. dEstimated effective pressure. eDirections of changes not reported in the study. fMeasured effective pressure.