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Table 3 AHI (events/hour) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study
PMID
Baseline AHI (SD)
[eligibility]
Baseline ESS (SD) Duration (design) Interventions Number analyzed Baseline (SD) Change
(final)
Net difference
or difference
95% CIa P Dropout (%) Study quality
d'Ortho 2000 [32]
11035671
58 (6)
[≥10]
12.7 (5.3) 2 months
(XO)
APAP 25 57.8 (5.8) -47.2 0.9 nd NS 0 B
     CPAP 25 57.8
(5.8)
-48.1      
Damjanovic 2009 [10]
19129293
44 (25)
[≥15]
8.8 (5.2) 3 months
(PL)
APAP 46 41.8 (23.7) -37.0 1.8 -7.14 to 10.74 nd 8 B
     CPAP 46 45.5 (24.4) -38.8      
    9 months
(PL)
APAP 34 41.8 (23.7) -38.2 1.9 -6.86 to 10.66 nd 22  
     CPAP 44 45.5 (24.4) -40.1      
Fietze 2007 [11]
17337881
42 (26)
[≥10]
nd 1.5 months
(PL)
APAP 20 43.3 (30.2) -38.9 0.5 -1.19 to 2.19 nd 0 C
     CPAP 21 40.4 (26.1) -36.5      
Galetke 2008 [12]
17148931
33 (19)
[> 10]
10.3 (5.7) 2 months
(XO)
APAP 20 32.9 (19.1) -27.3 1.0 -0.45 to 2.45 nd nd C
     CPAP 20 32.9 (19.1) -28.3      
Hussain 2004 [20]
15072173
47 (36)
[> 15]
11.1 (6.4) 1 month
(XO)
APAP 10 47.2 (35.6) -34.1 3.5 -1.02 to 8.02 nd 0 C
     CPAP 10 47.2 (35.6) -37.6      
Konermann 1998 [31]
9515848
38 (14)
[> 20]
nd 3 to 6 months
(PL)
APAP 25 35.5
(9.6)
-33.1 1.6 nd NS 4 B
     CPAP 23 38.3
(13.9)
-34.7      
Massie 2003 [22]
12406840
nd
[≥15]
nd 1.5 months
(XO)
APAP 44 nd nd -1.1 -2.89 to 0.69 nd 4 B
     CPAP 44 nd nd      
Meurice 2007 [13]
17638595
55 (10)
[nd]
11.8 (4.9) 6 months
(PL)
APAP (AutoSet) 15 53.4 (15.1) -51.1 2.6 -8.88 to 14.08 nd 15 B
     CPAP 14 56.1
(21.4)
-53.7      
Nolan 2007 [14]
17326544
15 (8)
[≥5)
12.3 (4.0) 2 months
(XO)
APAP 29 14.7 (8) -12.0 -0.8 -1.89 to 0.29b 0.15 15 B
     CPAP 29 14.7 (8) -11.2      
Nussbaumer 2006 [15]
16537862
41 (20)
[> 10]
12.7 (3.3) 1 month
(XO)
APAP 30 41.1 (19.7) -36.5 -0.8 -1.7 to 3.3c nd 12 B
     CPAP 30 41.2 (19.7) -35.7      
Patruno 2007 [16]
17494789
46 (14)
[> 20]
15 (2.7) 3 months
(PL)
APAP 15 47.3 (14.7) -41.3 2.7 -7.01 to 12.41 nd 23 C
     CPAP 16 46.0
(14.6)
-44.0      
Planes 2003 [29]
12683473
59 (17)
[≥30]
15.1 (3.9) 2 months
(PL)
APAP 16 57.5 (16.5) -49.9 0.7 -10.06 to 11.46 nd 14 C
     CPAP 14 61.0
(17.4)
-50.6      
Randerath 2001 [26]
11254519
35 (26)
[≥10]
11.1 (5.1) 1.5 months
(XO)
APAP 52 35.1 (26) -30.1 0.7 -0.88 to 2.28 nd 12 B
     CPAP 52 35.1 (26) -30.8      
Resta 2004 [24]
15679008
47 (11)
[> 30]
13.9 (3.2) 1 month
(PL)
APAP 10 48.0
(14.3)
-39.7 -2.8 -12.96 to 7.36 nd 0 C
     CPAP 10 45.3 (10.7) -36.9      
Senn 2003 [25]
Switzerland
14525804
46 (23)
[> 10]
14.2 (3.8) 1 month
(XO)
APAP (Autoset T) 29 45.8 (22.6) -39.8 0.7 -1.26 to 2.66 nd 7 B
     APAP (AutoAdjust) 29 45.8 (22.6) -38.1 2.4 -0.34 to 5.14 nd   
     CPAP 29 45.8
(22.6)
-40.5      
Sériès 1997 [27]
9341056
44 (20)
[nd]
15.5 (4.5) 0.75 months
(PL)
APAPd 12 61.5 (27.9) nde - - NS 0 C
     CPAP 12 50.1 (14.5) nd      
     APAPf 12 46.8 (22.3) nde - - NS   
     CPAP 12 50.1 (14.5) nd      
  1. AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cActual reported data. dEstimated effective pressure. eDirections of changes not reported in the study. fMeasured effective pressure.