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Table 2 Compliance (mean hours/night) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Baseline AHI (SD) [Eligibility] Baseline ESS (SD) Duration (design) Interventions Number analyzed Final Change (final) Net difference or difference P Dropout (%) Study quality
d'Ortho 2000 [32] 11035671 58 (6) [≥10] 12.7 (5.3) 2 months (XO) APAP 25 4.1 -0.6 -1.5, 0.32a 0.20 0 B
     CPAP 25 4.7      
Damjanovic 2009 [10] 19129293 44 (25) [≥15] 8.8 (5.2) 3 months (PL) APAP 46 5.4 0 -0.7, 0.7 nd 8 B
     CPAP 46 5.4      
    9 months (PL) APAP 34 5.2 0.1 -0.9, 1.1 nd 22  
     CPAP 44 5.1      
Fietze 2007 [11] 17337881 42 (26) [≥10] nd 1.5 months (PL) APAP 20 5.0 0.8 nd NS 0 C
     CPAP 21 4.2      
Galetke 2008 [12] 17148931 33 (19) [> 10] 10.3 (5.7) 2 months (XO) APAP 20 6.37 -0.01 -0.82, 0.8 nd nd C
     CPAP 20 6.38      
Hudgel 2000 [18] 10947032 30 (25) [nd] 16.0 (5.0) 3 months (XO) APAP 14 6.0 0.5 0.02, 0.98a < 0.04 35 C
     CPAP 19 5.5      
Hukins 2004 [19] 15683142 56 (nd) 12.5 (nd) 1 to 2 months (XO) APAP 46 5.05 0.19 -0.06, 0.44a 0.14 16 B
     CPAP 46 4.86      
Hussain 2004 [20] 15072173 47 (36) [> 15] 11.1 (6.4) 1 month (XO) APAP 10 4.3 0.6 -0.84, 2.04 nd 0 C
     CPAP 10 3.7      
Konermann 1998 [31] 9515848 38 (14) [> 20] nd 3 to 6 months (PL) APAP 25 6.5 0.8 0.19, 1.41a < 0.01 4 B
     CPAP 23 5.7      
Marrone 2004 [21] 15165530 68 (12) [30] 16.3 (5.0) 1 month (XO) APAP 22 4.9 0.5 -0.26, 1.26 nd 0 C
     CPAP 22 4.4      
Massie 2003 [22] 12406840 nd [≥15] nd 1.5 months (XO) APAP 44 5.1 0.58 0.18, 0.99a 0.005 4 B
     CPAP 44 4.52      
Meurice 2007 [13] 17638595 55 (10) [nd] 11.8 (4.9) 3 months (PL) APAP (AutoSet) 15 6.0 -0.1 -0.79, 0.59 nd 15 B
     CPAP 14 6.1      
    6 months (PL) APAP (AutoSet) 15 6.1 -0.4 -1.28, 0.48 nd 15  
     CPAP 14 6.5      
Nolan 2007 [14] 17326544 15 (8) [≥5] 12.3 (4.0) 2 months (XO) APAP 29 4.9 0 nd 0.94 15 B
     CPAP 29 4.9      
Noseda 2004 [23] 15249439 51 (25) [> 20] 10.7 (2.4) 2 months (XO) APAP 24 5.3 -0.2 -0.89, 0.49 nd 11 B
     CPAP 24 5.5      
Nussbaumer 2006 [15] 16537862 41 (20) [> 10] 12.7 (3.3) 1 month (XO) APAP 30 5.1 0.3 -0.29, 0.89 nd 12 B
     CPAP 30 4.8      
Patruno 2007 [16] 17494789 46 (14) [> 20] 15 (2.7) 3 months (PL) APAP 15 6.2 0.2 -0.25, 0.65 nd 23 C
     CPAP 16 6.0      
Planes 2003 [29] 12683473 59 (17) [≥30] 15.1 (3.9) 2 months (PL) APAP 16 4.5 -0.8 nd NS 14 C
     CPAP 14 5.3      
Randerath 2001 [26] 11254519 35 (26) [≥10] 11.1 (5.1) 1.5 months (XO) APAP 46 5.26 0 -0.44, 0.44 nd 12 B
     CPAP 46 5.26      
Resta 2004 [24] 15679008 47 (11) [> 30] 13.9 (3.2) 1 month (PL) APAP 10 5.2 -0.1 -1.12, 0.92 nd 0 C
     CPAP 10 5.3      
Senn 2003 [25] 14525804 46 (23) [> 10] 14.2 (3.8) 1 month (XO) APAP (Autoset T) 29 5.5 -0.1 nd NS 7 B
     APAP (AutoAdjust) 29 5.5 -0.1 nd NS   
     CPAP 29 5.6      
Sériès 1997 [27] 9341056 44 (20) [nd] 15.5 (4.5) 0.75 months (PL) APAPb 12 ndc - - NS 0 C
     CPAP 12 nd      
     APAPd 12 ndc - - NS   
     CPAP 12 nd      
Vennelle 2010 [30] 20175411 33 (18) [≥15] 14 (3) 6 weeks (XO) APAP 181 4.2 0.2 0.003, 0.397 0.047 9.5 A
     CPAP 181 4.0      
Teschler 2000 [28] 10885414 53 (26) [> 20] nd 2 months (XO) APAP 10 6.3 0.2 -0.7, 1.1 nd nd C
     CPAP 10 6.1      
To 2008 [17] 18197915 54 (nd) [> 30] 13.4 (nd) 1 month (XO) APAP 41 4.3 0.5 0.02, 0.98 0.04 5 B
     CPAP 41 3.8      
    2 months (XO) APAP 41 4.4 0.7 0.17, 1.23a 0.01   
     CPAP 41 3.7      
West 2006 [33] 16254055 33e (nd) [> 10] 16.5f (nd) 1 month (PL) APAP 29 5.3    0.27 6.1 A
     CPAP (auto) 31 4.3      
     CPAP (algo) 32 4.7      
    6 months (PL) APAP 28 5.5    0.23   
     CPAP (auto) 31 4.9      
     CPAP (algo) 27 4.0     9.2  
  1. AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported P value. bEstimated effective pressure. cDirections of changes not reported in the study. dMeasured effective pressure. e> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm, median. fMedian in algorithm-determined CPAP arm.