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Table 2 Compliance (mean hours/night) in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study
PMID
Baseline AHI (SD)
[Eligibility]
Baseline ESS (SD) Duration (design) Interventions Number analyzed Final Change
(final)
Net difference
or difference
P Dropout (%) Study quality
d'Ortho 2000 [32]
11035671
58 (6)
[≥10]
12.7 (5.3) 2 months
(XO)
APAP 25 4.1 -0.6 -1.5, 0.32a 0.20 0 B
     CPAP 25 4.7      
Damjanovic 2009 [10]
19129293
44 (25)
[≥15]
8.8 (5.2) 3 months
(PL)
APAP 46 5.4 0 -0.7, 0.7 nd 8 B
     CPAP 46 5.4      
    9 months
(PL)
APAP 34 5.2 0.1 -0.9, 1.1 nd 22  
     CPAP 44 5.1      
Fietze 2007 [11]
17337881
42 (26)
[≥10]
nd 1.5 months
(PL)
APAP 20 5.0 0.8 nd NS 0 C
     CPAP 21 4.2      
Galetke 2008 [12]
17148931
33 (19)
[> 10]
10.3 (5.7) 2 months
(XO)
APAP 20 6.37 -0.01 -0.82, 0.8 nd nd C
     CPAP 20 6.38      
Hudgel 2000 [18]
10947032
30 (25)
[nd]
16.0 (5.0) 3 months
(XO)
APAP 14 6.0 0.5 0.02, 0.98a < 0.04 35 C
     CPAP 19 5.5      
Hukins 2004 [19]
15683142
56 (nd) 12.5 (nd) 1 to 2 months
(XO)
APAP 46 5.05 0.19 -0.06, 0.44a 0.14 16 B
     CPAP 46 4.86      
Hussain 2004 [20]
15072173
47 (36)
[> 15]
11.1 (6.4) 1 month
(XO)
APAP 10 4.3 0.6 -0.84, 2.04 nd 0 C
     CPAP 10 3.7      
Konermann 1998 [31]
9515848
38 (14)
[> 20]
nd 3 to 6 months
(PL)
APAP 25 6.5 0.8 0.19, 1.41a < 0.01 4 B
     CPAP 23 5.7      
Marrone 2004 [21]
15165530
68 (12)
[30]
16.3 (5.0) 1 month
(XO)
APAP 22 4.9 0.5 -0.26, 1.26 nd 0 C
     CPAP 22 4.4      
Massie 2003 [22]
12406840
nd
[≥15]
nd 1.5 months
(XO)
APAP 44 5.1 0.58 0.18, 0.99a 0.005 4 B
     CPAP 44 4.52      
Meurice 2007 [13]
17638595
55 (10)
[nd]
11.8 (4.9) 3 months
(PL)
APAP (AutoSet) 15 6.0 -0.1 -0.79, 0.59 nd 15 B
     CPAP 14 6.1      
    6 months
(PL)
APAP (AutoSet) 15 6.1 -0.4 -1.28, 0.48 nd 15  
     CPAP 14 6.5      
Nolan 2007 [14]
17326544
15 (8)
[≥5]
12.3 (4.0) 2 months
(XO)
APAP 29 4.9 0 nd 0.94 15 B
     CPAP 29 4.9      
Noseda 2004 [23]
15249439
51 (25) [> 20] 10.7 (2.4) 2 months
(XO)
APAP 24 5.3 -0.2 -0.89, 0.49 nd 11 B
     CPAP 24 5.5      
Nussbaumer 2006 [15]
16537862
41 (20)
[> 10]
12.7 (3.3) 1 month
(XO)
APAP 30 5.1 0.3 -0.29, 0.89 nd 12 B
     CPAP 30 4.8      
Patruno 2007 [16]
17494789
46 (14)
[> 20]
15 (2.7) 3 months
(PL)
APAP 15 6.2 0.2 -0.25, 0.65 nd 23 C
     CPAP 16 6.0      
Planes 2003 [29]
12683473
59 (17)
[≥30]
15.1 (3.9) 2 months
(PL)
APAP 16 4.5 -0.8 nd NS 14 C
     CPAP 14 5.3      
Randerath 2001 [26]
11254519
35 (26)
[≥10]
11.1 (5.1) 1.5 months
(XO)
APAP 46 5.26 0 -0.44, 0.44 nd 12 B
     CPAP 46 5.26      
Resta 2004 [24]
15679008
47 (11)
[> 30]
13.9 (3.2) 1 month
(PL)
APAP 10 5.2 -0.1 -1.12, 0.92 nd 0 C
     CPAP 10 5.3      
Senn 2003 [25]
14525804
46 (23)
[> 10]
14.2 (3.8) 1 month
(XO)
APAP (Autoset T) 29 5.5 -0.1 nd NS 7 B
     APAP (AutoAdjust) 29 5.5 -0.1 nd NS   
     CPAP 29 5.6      
Sériès 1997 [27]
9341056
44 (20)
[nd]
15.5 (4.5) 0.75 months
(PL)
APAPb 12 ndc - - NS 0 C
     CPAP 12 nd      
     APAPd 12 ndc - - NS   
     CPAP 12 nd      
Vennelle 2010 [30]
20175411
33 (18) [≥15] 14 (3) 6 weeks (XO) APAP 181 4.2 0.2 0.003, 0.397 0.047 9.5 A
     CPAP 181 4.0      
Teschler 2000 [28]
10885414
53 (26)
[> 20]
nd 2 months
(XO)
APAP 10 6.3 0.2 -0.7, 1.1 nd nd C
     CPAP 10 6.1      
To 2008 [17]
18197915
54 (nd)
[> 30]
13.4 (nd) 1 month
(XO)
APAP 41 4.3 0.5 0.02, 0.98 0.04 5 B
     CPAP 41 3.8      
    2 months
(XO)
APAP 41 4.4 0.7 0.17, 1.23a 0.01   
     CPAP 41 3.7      
West 2006 [33]
16254055
33e (nd)
[> 10]
16.5f (nd) 1 month
(PL)
APAP 29 5.3    0.27 6.1 A
     CPAP (auto) 31 4.3      
     CPAP (algo) 32 4.7      
    6 months
(PL)
APAP 28 5.5    0.23   
     CPAP (auto) 31 4.9      
     CPAP (algo) 27 4.0     9.2  
  1. AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported P value. bEstimated effective pressure. cDirections of changes not reported in the study. dMeasured effective pressure. e> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm, median. fMedian in algorithm-determined CPAP arm.