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Table 11 Strength of evidence of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Outcomes Number of trials Total number Trials with data for Meta-analysis Meta-analysis results comparing APAP with CPAP Favors Strength of evidence
Clinical outcomes (death, cardiovascular events and others) 0 0 0 N/A   Insufficient
Compliance 24 1008 22 0.18 hours (95% CI 0.05 to 0.31; P = 0.006) APAP Moderate
Apnea-Hypopnea Index 16 548 16 0.25 events/hour (95% CI -0.16 to 0.66; NS) No difference Moderate
Epworth Sleepiness Scale 22 954 18 -0.48 (95% CI -0.81 to -0.15; P = 0.005) APAP Moderate
Arousal Index 10 356 9 -0.85 events/hour (95% CI -2.2 to 0.5; NS) No difference Moderate
Minimum O2 saturation 9 258 9 -1.3% (95% CI -2.2 to -0.4; P = 0.003) CPAP Moderate
Sleep efficiency 3 126 0   No difference Insufficient
Rapid eye movement sleep 9 273 0   No difference Moderate
Slow wave sleep 8 243 0   No difference in seven trials; one trial favored APAP Moderate
Quality of life 9 509 0   No difference in eight trials; one trial favored APAP Moderate
Blood pressure 3 149 0   No difference in two trials; one trial favored CPAP (decrease in diastolic blood pressure) Insufficient
  1. APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; N/A: not applicable; NS: non-significant.