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Table 10 Quality of life and functional outcomes in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Baseline AHI (SD) [eligibility] Baseline ESS (SD) Interventions Number analyzed Duration (design) Outcome Favors If significant difference Dropout (%) Study quality
         Net difference 95% CI Test range P   
           "Worst" "Best"    
Fietze 2007 [11] 17337881 42 (26) [≥10] nd APAP 20 1.5 months (XO) SF-36 all 0       0 C
    CPAP 21           
Hukins 2004 [19] 15683142 56 (nd) [≥5] 12.5 (nd) APAP 46 2 months (XO) SF-36-M 0       16 B
    CPAP 46           
       SF-36-P 0        
Massie 2003 [22] 12406840 nd [≥15] nd APAP 44 1.5 months (XO) SF-36 - MH APAP 5 0.16 to 9.8a 0 100 < 0.05 4 B
    CPAP 44   SF-36 - vitality APAP 7 0.6 to 13.4a 0 100 < 0.05   
       SF-36 - remainder 0        
Meurice 2007 [13] 17638595 55 (10) [nd] 11.8 (4.9) APAP (AutoSet) 15 3 months (PL) SF-36-M 0       15 B
    CPAP 14   SF-36-P 0        
      6 months (PL) SF-36-M 0       15  
       SF-36-P 0        
Nussbaumer 2006 [15] 16537862 41 (20) [> 10] 12.7 (3.3) APAP 30 1 month (XO) SF-36 all 0       12 B
    CPAP 30           
Senn 2003 [25] 14525804 46 (23) [> 10] 14.2 (3.8) APAP (Autoset T) 29 1 month (XO) SF-36 all 0       7 B
    APAP (AutoAdjust) 29   Vigilance (OSLER) 0        
    CPAP 29           
To 2008 [17] 18197915 54.3 (nd) [> 30] 13.4 (nd) APAP 41 1 month (XO) SAQLI 0       5 B
    CPAP 41 2 months (XO) SAQLI 0        
Vennelle 2010 [30] 20175411 33 (18) [≥15] 14 (3) APAP 181 6 weeks (XO) SF-36-M 0       9.5 A
    CPAP 181   SF-36-P 0        
       Vigilance (OSLER) 0        
       Vigilance (Psychomotor) 0        
West 2006 [33] 16254055 33b (nd) [> 10] 16.5c (nd) APAP 28 6 months (PL) SF-36-P 0       9.2  
    CPAP (auto) 31   SF-36-M 0        
    CPAP (algo) 27   SF-36-energy, vitality 0        
       Vigilance (OSLER) 0        
  1. AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; OSLER: The Oxford Sleep Resistance Test; SAQLI: Sleep Apnea Quality of Life Index; XO: cross-over design. SF-36 M: Short Form Health Survey Mental Health summary measure. SF_36 P: Short Form Health Survey Physical Health summary measure. SF-36 MH: Short Form Health Survey Mental Health scale. aEstimated from reported P value. b> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm. cMedian in algorithm-determined CPAP arm.