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Table 10 Quality of life and functional outcomes in randomized controlled trials of APAP versus CPAP

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study

PMID

Baseline AHI (SD)

[eligibility]

Baseline ESS (SD)

Interventions

Number analyzed

Duration (design)

Outcome

Favors

If significant difference

Dropout (%)

Study quality

        

Net difference

95% CI

Test range

P

  
          

"Worst"

"Best"

   

Fietze 2007 [11]

17337881

42 (26)

[≥10]

nd

APAP

20

1.5 months

(XO)

SF-36

all

0

     

0

C

   

CPAP

21

          

Hukins 2004 [19]

15683142

56 (nd)

[≥5]

12.5 (nd)

APAP

46

2 months

(XO)

SF-36-M

0

     

16

B

   

CPAP

46

          
      

SF-36-P

0

       

Massie 2003 [22]

12406840

nd

[≥15]

nd

APAP

44

1.5 months

(XO)

SF-36 - MH

APAP

5

0.16 to 9.8a

0

100

< 0.05

4

B

   

CPAP

44

 

SF-36 - vitality

APAP

7

0.6 to 13.4a

0

100

< 0.05

  
      

SF-36 -

remainder

0

       

Meurice 2007 [13]

17638595

55 (10)

[nd]

11.8 (4.9)

APAP (AutoSet)

15

3 months

(PL)

SF-36-M

0

     

15

B

   

CPAP

14

 

SF-36-P

0

       
     

6 months

(PL)

SF-36-M

0

     

15

 
      

SF-36-P

0

       

Nussbaumer 2006 [15]

16537862

41 (20)

[> 10]

12.7 (3.3)

APAP

30

1 month

(XO)

SF-36

all

0

     

12

B

   

CPAP

30

          

Senn 2003 [25]

14525804

46 (23)

[> 10]

14.2 (3.8)

APAP (Autoset T)

29

1 month

(XO)

SF-36

all

0

     

7

B

   

APAP (AutoAdjust)

29

 

Vigilance (OSLER)

0

       
   

CPAP

29

          

To 2008 [17]

18197915

54.3 (nd)

[> 30]

13.4 (nd)

APAP

41

1 month

(XO)

SAQLI

0

     

5

B

   

CPAP

41

2 months

(XO)

SAQLI

0

       

Vennelle 2010 [30]

20175411

33 (18) [≥15]

14 (3)

APAP

181

6 weeks (XO)

SF-36-M

0

     

9.5

A

   

CPAP

181

 

SF-36-P

0

       
      

Vigilance (OSLER)

0

       
      

Vigilance

(Psychomotor)

0

       

West 2006 [33]

16254055

33b (nd)

[> 10]

16.5c (nd)

APAP

28

6 months (PL)

SF-36-P

0

     

9.2

 
   

CPAP (auto)

31

 

SF-36-M

0

       
   

CPAP (algo)

27

 

SF-36-energy, vitality

0

       
      

Vigilance (OSLER)

0

       
  1. AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; OSLER: The Oxford Sleep Resistance Test; SAQLI: Sleep Apnea Quality of Life Index; XO: cross-over design. SF-36 M: Short Form Health Survey Mental Health summary measure. SF_36 P: Short Form Health Survey Physical Health summary measure. SF-36 MH: Short Form Health Survey Mental Health scale. aEstimated from reported P value. b> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm. cMedian in algorithm-determined CPAP arm.