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Table 1 Randomized controlled trials of APAP versus CPAP: baseline study characteristics

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study PMID Study design Mean age (years) Male, % Mean body mass index (kg/m2) Baseline AHI (SD) Previous CPAP? Funding Quality issues
d'Ortho 2000 [32] 11035671 XO 57 88 32 58 (6) No Industry/Non-industry combined -
Damjanovic 2009 [10] 19129293 PL 57 78 31.1 44 (25) No (new Dx) nd -
Fietze 2007 [11] 17337881 PL 54 95 30.9 42 (26) No (new Dx) Industry Incomplete reporting; patient selection unclear
Galetke 2008 [12] 17148931 XO 56 80 29.3 33 (19) No (new Dx) nd Incomplete reporting; small sample and no power calculation
Hudgel 2000 [18] 10947032 XO 46 54 42 30 (25) No nd Incomplete reporting; 35% dropout
Hukins 2004 [19] 15683142 XO 50 87 35.2 50 (25) No Industry -
Hussain 2004 [20] 15072173 XO 45 90 35.9 47 (36) No Industry Patient recruitment method unclear; small sample and no power calculation
Konermann 1998 [31] 9515848 PL 54 88 32.1 38 (14) nd nd -
Marrone 2004 [21] 15165530 XO 53 95 32.9 68 (12) No nd Small sample and no power calculation
Massie 2003 [22] 12406840 XO 49 82 32 nd No (new Dx, implied) Industry Incomplete reporting
Meurice 2007 [13] 17638595 PL 55 nd 30.8 55 (10) No (no Tx) nd Patient recruitment unclear
Nolan 2007 [14] 17326544 XO 53 90 29.9 15 (8) No (new Dx) Non-industry -
Noseda 2004 [23] 15249439 XO 49 96 32.3 nd No nd -
Nussbaumer 2006 [15] 16537862 XO 49 90 31.1 41 (20) nd Industry -
Patruno 2007 [16] 17494789 PL 48 81 36.5 46 (14) No (new Dx) Non-industry Incomplete reporting
Planes 2003 [29] 12683473 PL 54 77 32.4 59 (17) No (new Dx) Industry (unclear) Patient recruitment unclear
Randerath 2001 [26] 11254519 XO 55 87 32.4 35 (26) nd Industry -
Resta 2004 [24] 15679008 PL 33 90 36.7 47 (11) No (no Tx) nd Incomplete reporting
Senn 2003 [25] 14525804 XO 53 79 33.3 46 (23) No nd -
Sériès 1997 [27] 9341056 PL 36-65 (range) nd 36.4 44 (20) No (no Tx) Industry Potential selection bias
Teschler 2000 [28] 10885414 XO 52 100 33.8 53 (26) No (new Dx) nd Incomplete reporting; small sample
To 2008 [17] 18197915 XO 46 nd 28.7 54 (nd) No (new Dx) nd -
Vennelle 2010 [30] 20175411 XO 50 77 34.5 33 (18) No (new Dx) nd -
West 2006 [33] 16254055 PL 46.5a 85 nd nd No Industry -
  1. APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; nd: no data; new Dx: a new diagnosis of sleep apnea; no Tx: no prior treatment; PL: parallel; XO: cross-over. aMedian of the CPAP arm.