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Table 1 Randomized controlled trials of APAP versus CPAP: baseline study characteristics

From: Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses

Study
PMID
Study design Mean age (years) Male, % Mean body mass index (kg/m2) Baseline AHI (SD) Previous CPAP? Funding Quality issues
d'Ortho 2000 [32]
11035671
XO 57 88 32 58 (6) No Industry/Non-industry combined -
Damjanovic 2009 [10]
19129293
PL 57 78 31.1 44 (25) No
(new Dx)
nd -
Fietze 2007 [11]
17337881
PL 54 95 30.9 42 (26) No
(new Dx)
Industry Incomplete reporting; patient selection unclear
Galetke 2008 [12]
17148931
XO 56 80 29.3 33 (19) No
(new Dx)
nd Incomplete reporting; small sample and no power calculation
Hudgel 2000 [18]
10947032
XO 46 54 42 30 (25) No nd Incomplete reporting; 35% dropout
Hukins 2004 [19]
15683142
XO 50 87 35.2 50 (25) No Industry -
Hussain 2004 [20]
15072173
XO 45 90 35.9 47 (36) No Industry Patient recruitment method unclear; small sample and no power calculation
Konermann 1998 [31]
9515848
PL 54 88 32.1 38 (14) nd nd -
Marrone 2004 [21]
15165530
XO 53 95 32.9 68 (12) No nd Small sample and no power calculation
Massie 2003 [22]
12406840
XO 49 82 32 nd No
(new Dx, implied)
Industry Incomplete reporting
Meurice 2007 [13]
17638595
PL 55 nd 30.8 55 (10) No
(no Tx)
nd Patient recruitment unclear
Nolan 2007 [14]
17326544
XO 53 90 29.9 15 (8) No
(new Dx)
Non-industry -
Noseda 2004 [23]
15249439
XO 49 96 32.3 nd No nd -
Nussbaumer 2006 [15]
16537862
XO 49 90 31.1 41 (20) nd Industry -
Patruno 2007 [16]
17494789
PL 48 81 36.5 46 (14) No
(new Dx)
Non-industry Incomplete reporting
Planes 2003 [29]
12683473
PL 54 77 32.4 59 (17) No
(new Dx)
Industry (unclear) Patient recruitment unclear
Randerath 2001 [26]
11254519
XO 55 87 32.4 35 (26) nd Industry -
Resta 2004 [24]
15679008
PL 33 90 36.7 47 (11) No
(no Tx)
nd Incomplete reporting
Senn 2003 [25]
14525804
XO 53 79 33.3 46 (23) No nd -
Sériès 1997 [27]
9341056
PL 36-65 (range) nd 36.4 44 (20) No
(no Tx)
Industry Potential selection bias
Teschler 2000 [28]
10885414
XO 52 100 33.8 53 (26) No
(new Dx)
nd Incomplete reporting; small sample
To 2008 [17]
18197915
XO 46 nd 28.7 54 (nd) No
(new Dx)
nd -
Vennelle 2010 [30]
20175411
XO 50 77 34.5 33 (18) No
(new Dx)
nd -
West 2006 [33]
16254055
PL 46.5a 85 nd nd No Industry -
  1. APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; nd: no data; new Dx: a new diagnosis of sleep apnea; no Tx: no prior treatment; PL: parallel; XO: cross-over. aMedian of the CPAP arm.