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Table 1 Eligible trials with their inclusion criteria and corticosteroid regimens as at September 2011

From: Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: assessing the effects using the best level of evidence) - study protocol

TRIAL Gestational age at entry (weeks) Repeat corticosteroid timing Repeat corticosteroid regimen Number of repeat courses
Garite 2009[20] 25 to < 33 Birth expected < 7 days 2 × 12 mg betamethasone 24 hours apart; or 4 × 6 mg dexamethasone 12 hours apart 1
Peltoniemi 2007[25] < 34 Birth expected < 48 hours 1 × 12 mg betamethasone 1
Aghajafari 2002[18] 24 to 30 Weekly until 33 weeks, or birth if still at risk of preterm birth 2 × 12 mg betamethasone 24 hours apart varied
Crowther 2006[19] < 32 Weekly until < 32 weeks, and if still at risk of preterm birth 1 × 11.4 mg betamethasone varied
Guinn 2001[21] 24 to < 33 Weekly until 34 weeks 2 × 12 mg betamethasone 24 hours apart varied
Mazumder 2008[22] 26 to 33 Weekly until < 34 weeks 2 × 12 mg betamethasone 24 hours apart varied
McEvoy 2002[23] 25 to 33 Weekly until 34 weeks 2 × 12 mg betamethasone 24 hours apart varied
McEvoy 2010[27] 26 to 34 Rescue course 14 days after initial dose; < 34 weeks 2 × 12 mg betamethasone 24 hours apart 1
Murphy 2006[24] 25 to 32 Fortnightly until 33 weeks 2 × 12 mg betamethasone 24 hours apart varied
Wapner 2006[26] 23 to < 32 Weekly until < 34 weeks 2 × 12 mg betamethasone; 24 hours apart varied
Brocklehurst[14] < 32 Weekly (with 10 and 14 day intervals being used in some centres) 2 × 12 mg betamethasone; 12 or 24
hours apart.
varied