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  1. Protocol

    An assessment of the factors affecting the commercialization of cell-based therapeutics: a systematic review protocol

    Cellular-based therapies represent a platform technology within the rapidly expanding field of regenerative medicine and are distinct from conventional therapeutics—offering a unique approach to managing what ...

    David Pettitt, Zeeshaan Arshad, Benjamin Davies, James Smith, Anna French, Doug Cole, Kim Bure, Sue Dopson, David DiGiusto, Jeff Karp, Brock Reeve, Richard Barker, Georg Holländer and David Brindley

    Systematic Reviews 2017 6:120

    Published on: 26 June 2017

  2. Protocol

    An investigation of the impact of using different methods for network meta-analysis: a protocol for an empirical evaluation

    Network meta-analysis, a method to synthesise evidence from multiple treatments, has increased in popularity in the past decade. Two broad approaches are available to synthesise data across networks, namely, a...

    Amalia (Emily) Karahalios, Georgia Salanti, Simon L. Turner, G. Peter Herbison, Ian R. White, Areti Angeliki Veroniki, Adriani Nikolakopoulou and Joanne E. Mckenzie

    Systematic Reviews 2017 6:119

    Published on: 24 June 2017

  3. Protocol

    Stress ulcer prophylaxis versus placebo or no prophylaxis in adult hospitalised acutely ill patients—protocol for a systematic review with meta-analysis and trial sequential analysis

    Stress ulcer prophylaxis is considered standard of care in many critically ill patients in the intensive care unit (ICU). However, the quality of evidence supporting this has recently been questioned, and clin...

    Søren Marker, Anders Perner, Jørn Wetterslev, Marija Barbateskovic, Janus Christian Jakobsen, Mette Krag, Anders Granholm, Carl Thomas Anthon and Morten Hylander Møller

    Systematic Reviews 2017 6:118

    Published on: 24 June 2017

  4. Protocol

    Effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery: protocol for a systematic review, meta-analysis, and trial sequential analysis

    Preliminary evidence suggests statins may reduce major perioperative vascular events. However, evidence is limited to observational studies, underpowered trials, and non-comprehensive systematic reviews. This ...

    Erica Aranha Suzumura, Rodrigo Antonini Ribeiro, Leticia Kawano-Dourado, Pedro Gabriel de Barros e Silva, Claudia Oliveira, Mabel Fernandes Figueiró, Alexandre Biasi Cavalcanti, Renato D. Lopes and Otavio Berwanger

    Systematic Reviews 2017 6:116

    Published on: 19 June 2017

  5. Research

    Identifying approaches for assessing methodological and reporting quality of systematic reviews: a descriptive study

    The methodological quality and completeness of reporting of the systematic reviews (SRs) is fundamental to optimal implementation of evidence-based health care and the reduction of research waste. Methods exis...

    Kusala Pussegoda, Lucy Turner, Chantelle Garritty, Alain Mayhew, Becky Skidmore, Adrienne Stevens, Isabelle Boutron, Rafael Sarkis-Onofre, Lise M. Bjerre, Asbjørn Hróbjartsson, Douglas G. Altman and David Moher

    Systematic Reviews 2017 6:117

    Published on: 19 June 2017

  6. Protocol

    Development of a program theory for shared decision-making: a realist review protocol

    The practicality of applying evidence to healthcare systems with the aim of implementing change is an ongoing challenge for practitioners, policy makers, and academics. Shared decision- making (SDM), a method ...

    Gary Groot, Tamara Waldron, Tracey Carr, Linda McMullen, Lori-Ann Bandura, Shelley-May Neufeld and Vicky Duncan

    Systematic Reviews 2017 6:114

    Published on: 17 June 2017

  7. Protocol

    Interventions to prevent hemodynamic instability during renal replacement therapy for acute kidney injury: a systematic review protocol

    Hemodynamic instability during renal replacement therapy (HIRRT) in the form of intradialytic hypotension (IDH) is a frequent complication of hemodialysis in end-stage kidney disease (ESKD), and most studies h...

    Adrianna Douvris, Swapnil Hiremath, Lauralyn McIntyre, Lindsey Sikora, Catherine Weber and Edward G. Clark

    Systematic Reviews 2017 6:113

    Published on: 15 June 2017

  8. Protocol

    Psychological interventions for the treatment of depression, anxiety, alcohol misuse or anger in armed forces veterans and their families: systematic review and meta-analysis protocol

    Evidence highlights a high prevalence of common mental health disorders in armed forces veterans and their families, with depression, anxiety, alcohol misuse and anger being more common than PTSD. This paper p...

    Luke O’Shea, Ed Watkins and Paul Farrand

    Systematic Reviews 2017 6:112

    Published on: 15 June 2017

  9. Protocol

    Protocol for a systematic review of the efficacy of fat grafting and platelet-rich plasma for wound healing

    The use of fat grafting as a reconstructive surgical option is becoming much more common. Adipose-derived stem cells found in fat grafts are believed to facilitate wound healing via differentiation into fibrob...

    Oliver J. Smith, Muholan Kanapathy, Ankur Khajuria, Max Prokopenko, Nadine Hachach-Haram, Haroon Mann and Ash Mosahebi

    Systematic Reviews 2017 6:111

    Published on: 6 June 2017

  10. Protocol

    Parent experiences and information needs relating to procedural pain in children: a systematic review protocol

    There exist many evidence-based interventions available to manage procedural pain in children and neonates, yet they are severely underutilized. Parents play an important role in the management of their child’...

    Allison Gates, Kassi Shave, Robin Featherstone, Kelli Buckreus, Samina Ali, Shannon Scott and Lisa Hartling

    Systematic Reviews 2017 6:109

    Published on: 6 June 2017

  11. Research

    Do outcomes reported in randomised controlled trials of joint replacement surgery fulfil the OMERACT 2.0 Filter? A review of the 2008 and 2013 literature

    It is not known, whether outcome reporting in trials of total joint arthroplasty in the recent years is adequate or not. Our objective was to assess whether outcomes reported in total joint replacement (TJR) t...

    Peter D. H. Wall, Bethan L. Richards, Andrew Sprowson, Rachelle Buchbinder and Jasvinder A. Singh

    Systematic Reviews 2017 6:106

    Published on: 30 May 2017

  12. Research

    Conclusions in systematic reviews of mammography for breast cancer screening and associations with review design and author characteristics

    Debates about the benefits and harms of mammography continue despite the accumulation of evidence. We sought to quantify the disagreement across systematic reviews of mammography and determine whether author o...

    Smriti Raichand, Adam G. Dunn, Mei-Sing Ong, Florence T. Bourgeois, Enrico Coiera and Kenneth D. Mandl

    Systematic Reviews 2017 6:105

    Published on: 22 May 2017

  13. Protocol

    Polypharmacy in multimorbid older adults: protocol for a systematic review

    Polypharmacy, the concurrent use of multiple medications, consistently evokes a negative connotation, notably because it is associated with a plethora of adverse events. Nonetheless, the number of individuals ...

    Caroline Sirois, Marie-Laure Laroche, Line Guénette, Edeltraut Kröger, Dan Cooper and Valérie Émond

    Systematic Reviews 2017 6:104

    Published on: 19 May 2017

  14. Protocol

    Comparison of the effect of oral care with four different antiseptics to prevent ventilator-associated pneumonia in adults: protocol for a network meta-analysis

    Ventilator-associated pneumonia (VAP) is defined as the occurrence of pneumonia in patients receiving mechanical ventilation for more than 48 h after endotracheal intubation. The implementation of effective or...

    Zhigang Zhang, Yuying Hou, Jun Zhang, Bo Wang, Juxia Zhang, Ailing Yang, Ge Li and Jinhui Tian

    Systematic Reviews 2017 6:103

    Published on: 19 May 2017

  15. Protocol

    Why are some people more fit than others? Correlates and determinants of cardiorespiratory fitness in adults: protocol for a systematic review

    Cardiorespiratory fitness (CRF) is a physical condition that is now well established as a predictor of numerous adverse health outcomes, independent of physical activity levels. In order to be able to improve ...

    Nita Perumal, Gert B.M. Mensink, Thomas Keil and Jonas David Finger

    Systematic Reviews 2017 6:102

    Published on: 18 May 2017

  16. Research

    An overview of systematic reviews of complementary and alternative therapies for fibromyalgia using both AMSTAR and ROBIS as quality assessment tools

    Fibromyalgia (FM) is a chronic, debilitating pain disorder. Dissatisfaction with conventional medicine can lead people with FM to turn to complementary and alternative medicine (CAM). Two previous overviews of...

    Rachel Perry, Verity Leach, Philippa Davies, Chris Penfold, Andy Ness and Rachel Churchill

    Systematic Reviews 2017 6:97

    Published on: 15 May 2017

  17. Protocol

    Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage: a protocol for a systematic review

    Hyperglycaemia-induced oxidative damage is a well-established factor implicated in the development of diabetic cardiomyopathy (DCM) in diabetic individuals. Some of the well-known characteristics of DCM includ...

    Phiwayinkosi V. Dludla, Bongani B. Nkambule, Stephanie C. Dias and Rabia Johnson

    Systematic Reviews 2017 6:96

    Published on: 12 May 2017

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