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  1. Research

    The risk associated with spinal manipulation: an overview of reviews

    Spinal manipulative therapy (SMT) is a widely used manual treatment, but many reviews exist with conflicting conclusions about the safety of SMT. We performed an overview of reviews to elucidate and quantify t...

    Sabrina Mai Nielsen, Simon Tarp, Robin Christensen, Henning Bliddal, Louise Klokker and Marius Henriksen

    Systematic Reviews 2017 6:64

    Published on: 24 March 2017

  2. Protocol

    An evaluation of the comparative effectiveness of geriatrician-led comprehensive geriatric assessment for improving patient and healthcare system outcomes for older adults: a protocol for a systematic review and network meta-analysis

    Comprehensive geriatric assessment (CGA) is an integrated model of care involving a geriatrician and an interdisciplinary team and can prioritize and manage complex health needs of older adults with multimorbi...

    Charlene Soobiah, Caitlin Daly, Erik Blondal, Joycelyne Ewusie, Joanne Ho, Meghan J. Elliott, Rossini Yue, Jayna Holroyd-Leduc, Barbara Liu, Sharon Marr, Jenny Basran, Andrea C. Tricco, Jemila Hamid and Sharon E. Straus

    Systematic Reviews 2017 6:65

    Published on: 24 March 2017

  3. Research

    Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis

    A rigorous systematic review and meta-analysis focused on randomised controlled trials (RCTs) of non-individualised homeopathic treatment has not previously been reported. We tested the null hypothesis that th...

    Robert T. Mathie, Nitish Ramparsad, Lynn A. Legg, Jürgen Clausen, Sian Moss, Jonathan R. T. Davidson, Claudia-Martina Messow and Alex McConnachie

    Systematic Reviews 2017 6:63

    Published on: 24 March 2017

  4. Research

    Convergent and sequential synthesis designs: implications for conducting and reporting systematic reviews of qualitative and quantitative evidence

    Systematic reviews of qualitative and quantitative evidence can provide a rich understanding of complex phenomena. This type of review is increasingly popular, has been used to provide a landscape of existing ...

    Quan Nha Hong, Pierre Pluye, Mathieu Bujold and Maggy Wassef

    Systematic Reviews 2017 6:61

    Published on: 23 March 2017

  5. Protocol

    Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism—protocol for a systematic review

    Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adve...

    Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce and Scott Wilkes

    Systematic Reviews 2017 6:60

    Published on: 21 March 2017

  6. Protocol

    Economic evaluation of interventions delivered by primary care providers to improve neurodevelopment in children aged under 5 years: protocol for a scoping review

    Frequently cited benefit-cost ratios suggest that interventions to improve neurodevelopment have high economic returns when implemented during pregnancy and early childhood. However, there are many challenges ...

    Karen M. Edmond, Natalie A. Strobel, Kimberley McAuley, Elizabeth Geelhoed and Lisa Hurt

    Systematic Reviews 2017 6:59

    Published on: 21 March 2017

  7. Protocol

    Impact of different dietary approaches on glycemic control and cardiovascular risk factors in patients with type 2 diabetes: a protocol for a systematic review and network meta-analysis

    Dietary advice is one of the cornerstones in the management of type 2 diabetes mellitus. The American Diabetes Association recommended a hypocaloric diet for overweight or obese adults with type 2 diabetes in ...

    Lukas Schwingshackl, Anna Chaimani, Georg Hoffmann, Carolina Schwedhelm and Heiner Boeing

    Systematic Reviews 2017 6:57

    Published on: 20 March 2017

  8. Methodology

    Five shared decision-making tools in 5 months: use of rapid reviews to develop decision boxes for seniors living with dementia and their caregivers

    Decision support tools build upon comprehensive and timely syntheses of literature. Rapid reviews may allow supporting their development by omitting certain components of traditional systematic reviews. We thu...

    Moulikatou Adouni Lawani, Béatriz Valéra, Émilie Fortier-Brochu, France Légaré, Pierre-Hugues Carmichael, Luc Côté, Philippe Voyer, Edeltraut Kröger, Holly Witteman, Charo Rodriguez and Anik M. C. Giguere

    Systematic Reviews 2017 6:56

    Published on: 15 March 2017

  9. Research

    Relationship between family caregiver burden and physical frailty in older adults without dementia: a systematic review

    Physical frailty is a prevalent syndrome in older adults that increases vulnerability for a range of adverse outcomes including increased dependency and death. Caregivers of older adults experience significant...

    Thom Ringer, Afeez Abiola Hazzan, Arnav Agarwal, Adam Mutsaers and Alexandra Papaioannou

    Systematic Reviews 2017 6:55

    Published on: 14 March 2017

  10. Research

    Outcomes of dysvascular partial foot amputation and how these compare to transtibial amputation: a systematic review for the development of shared decision-making resources

    Dysvascular partial foot amputation (PFA) is a common sequel to advanced peripheral vascular disease. Helping inform difficult discussions between patients and practitioners about the level of PFA, or the deci...

    Michael P. Dillon, Matthew Quigley and Stefania Fatone

    Systematic Reviews 2017 6:54

    Published on: 14 March 2017

  11. Protocol

    The effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on longer-term maternal and early childhood outcomes: protocol for an individual participant data (IPD) meta-analysis

    The aim of this individual participant data meta-analysis (IPDMA) is to evaluate the effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on later maternal and early ...

    Jodie M. Dodd, Rosalie M. Grivell, Jennie Louise, Andrea R. Deussen, Lynne Giles, Ben W. Mol, Christina Vinter, Mette Tanvig, Dorte Moller Jensen, Annick Bogaerts, Roland Devlieger, Riitta Luoto, Fionnuala McAuliffe, Kristina Renault, Emma Carlsen, Nina Geiker…

    Systematic Reviews 2017 6:51

    Published on: 9 March 2017

  12. Protocol

    Risk factors for the development of autism spectrum disorder in children with tuberous sclerosis complex: protocol for a systematic review

    Tuberous sclerosis complex (TSC) is an autosomal dominant condition, caused by mutations in either the TSC1 or TSC2 gene. It has widespread systemic manifestations and is associated with significant neurologic...

    Rebecca Mitchell, Sarah Barton, A. Simon Harvey and Katrina Williams

    Systematic Reviews 2017 6:49

    Published on: 8 March 2017

  13. Protocol

    Findings, phenotypes, and outcomes in Freeman-Sheldon and Sheldon-Hall syndromes and distal arthrogryposis types 1 and 3: protocol for systematic review and patient-level data meta-analysis

    Freeman-Sheldon and Sheldon-Hall syndromes (FSS and SHS) and distal arthrogryposis types 1 and 3 (DA1 and DA3) are rare, often confused, congenital syndromes. Few studies exist. With reported diagnosis unrelia...

    Mikaela I. Poling, José Andrés Morales Corado and Robert L. Chamberlain

    Systematic Reviews 2017 6:46

    Published on: 6 March 2017

  14. Protocol

    The effects of rhythm control strategies versus rate control strategies for atrial fibrillation and atrial flutter: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis

    Atrial fibrillation is the most common arrhythmia of the heart with a prevalence of approximately 2% in the western world. Atrial flutter, another arrhythmia, occurs less often with an incidence of approximate...

    Naqash J. Sethi, Sanam Safi, Emil E. Nielsen, Joshua Feinberg, Christian Gluud and Janus C. Jakobsen

    Systematic Reviews 2017 6:47

    Published on: 6 March 2017

  15. Research

    Are child-centric aspects in newborn and child health systematic review and meta-analysis protocols and reports adequately reported?—two systematic reviews

    Evidence suggests that newborn and child health systematic reviews and meta-analyses exhibit poor quality in reporting. The “Preferred Reporting Items in Systematic Review and Meta-Analysis” (PRISMA) and PRISM...

    Mufiza Farid-Kapadia, Kariym C. Joachim, Chrinna Balasingham, April Clyburne-Sherin and Martin Offringa

    Systematic Reviews 2017 6:31

    Published on: 6 March 2017

  16. Research

    The number of stimuli required to reliably assess corticomotor excitability and primary motor cortical representations using transcranial magnetic stimulation (TMS): a systematic review and meta-analysis

    Transcranial magnetic stimulation (TMS) is a non-invasive means by which to assess the structure and function of the central nervous system. Current practices involve the administration of multiple stimuli ove...

    Rocco Cavaleri, Siobhan M. Schabrun and Lucy S. Chipchase

    Systematic Reviews 2017 6:48

    Published on: 6 March 2017

  17. Research

    Effect of standardized training on the reliability of the Cochrane risk of bias assessment tool: a prospective study

    The Cochrane risk of bias tool is commonly criticized for having a low reliability. We aimed to investigate whether training of raters, with objective and standardized instructions on how to assess risk of bia...

    Bruno R. da Costa, Brooke Beckett, Alison Diaz, Nina M. Resta, Bradley C. Johnston, Matthias Egger, Peter Jüni and Susan Armijo-Olivo

    Systematic Reviews 2017 6:44

    Published on: 3 March 2017

  18. Protocol

    Evaluating overweight and obesity prevalence in survivors of childhood brain tumors: a systematic review protocol

    Overweight and obesity are well-known risk factors for cardiometabolic diseases including hypertension, myocardial infarction, stroke, and type 2 diabetes in the general population. Survivors of childhood brai...

    Kuan-Wen Wang, Adam Fleming, Sheila K. Singh, Laura Banfield, Russell J. de Souza, Lehana Thabane and M. Constantine Samaan

    Systematic Reviews 2017 6:43

    Published on: 3 March 2017

  19. Protocol

    Protocol for a systematic review with network meta-analysis of the modalities used to deliver eHealth interventions for chronic pain

    As eHealth interventions prove both efficacious and practical, and as they arguably overcome certain barriers encountered by traditional face-to-face treatment for chronic pain, their number has increased dram...

    Brian W. Slattery, Stephanie Haugh, Kady Francis, Laura O’Connor, Katie Barrett, Christopher P. Dwyer, Siobhan O’Higgins, Jonathan Egan and Brian E. McGuire

    Systematic Reviews 2017 6:45

    Published on: 3 March 2017

  20. Protocol

    Non-pharmacological interventions designed to reduce health risks due to unhealthy eating behaviour and linked risky or excessive drinking in adults aged 18–25 years: a systematic review protocol

    Excess body weight and heavy alcohol consumption are two of the greatest contributors to global disease. Alcohol use peaks in early adulthood. Alcohol consumption can also exacerbate weight gain. A high body m...

    Stephanie Scott, Kathryn Parkinson, Eileen Kaner, Shannon Robalino, Martine Stead, Christine Power, Niamh Fitzgerald, Wendy Wrieden and Ashley Adamson

    Systematic Reviews 2017 6:42

    Published on: 3 March 2017

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