Factors associated with development of gastrointestinal problems in patients with scleroderma: a systematic review
© Hong et al. 2015
Received: 27 February 2015
Accepted: 21 December 2015
Published: 30 December 2015
Up to 90 % of people with scleroderma have gastrointestinal (GI) problems such as constipation, bloating, diarrhea, and malabsorption. These problems significantly impair quality of life. Our objective was to determine the risk factors for gastrointestinal issues in people with scleroderma.
We conducted a systematic review of observational studies that report GI problems in patients with scleroderma along with the associated risk factors. We were interested in any GI problem and any risk factor as long as the study included patients diagnosed with scleroderma according to the 1980 or 2013 American College of Rheumatology guideline. We searched the following databases: CINAHL, EMBASE, LILACS, MEDLINE, and Web of Science for relevant articles from June 1884 to May 2014. Two authors independently screened citations and full text articles and extracted data. Discrepancies were resolved by consensus or by consulting a third author. Methodological quality of included studies was assessed using the Newcastle-Ottawa Scale.
After removing duplicates, 645 unique citations were identified. A total of three studies, three cross-sectional (n = 64, n = 42, n = 606), were included in this systematic review. Collectively, these three studies explored Helicobacter pylori and smoking status as risk factors. We found conflicting evidence on the role of H. pylori with two studies showing opposite yet statistically significant results. One moderate quality study showed smoking as a risk factor. Key limitations include the small sample sizes of two studies and poor study designs to draw causal links.
There is insufficient evidence to describe the risk factors for GI problems in patients with scleroderma. Longitudinal observational studies are warranted in patients with scleroderma.
Systematic review registration
KeywordsSystematic review Scleroderma Gastrointestinal Risk factors
Scleroderma, otherwise known as systemic sclerosis, is a disease manifested by collagen overproduction affecting various organs including the gastrointestinal (GI) tract . Patients with scleroderma commonly present with inflammation and fibrosis of the skin, vascular abnormalities, organ damage, and autoantibody production . Diagnosis is made when these signs and corresponding symptoms are present . Scleroderma is a debilitating disease that is estimated to affect approximately 16,000 Canadians—with four to five times more females than males . The prevalence of the disease is higher among people of African origin and varies across countries, appearing more in North America and Australia than in Europe and Japan . Scleroderma is associated with debilitating morbidity such as reduction in mobility and depression . Patients with this disorder have a 30.8 % mortality rate, although this number can vary depending on gender and which visceral organs are involved . Currently, there are no effective treatments to combat scleroderma, partly because its pathogenesis remains unclear . Consequently, much attention has shifted towards predicting the complications of scleroderma and managing them appropriately . The underlying rationale is that it is easier to manage the disease before these complications arise .
In around 90 % of all patients with scleroderma, the GI tract is involved. This contributes considerably to impairment in quality of life [9–11]. Malabsorption, gastroesophageal reflux, nausea, vomiting, diarrhea, and constipation are some of the GI complications that can occur . Although environmental risk factors are clearly linked to increased risk of developing scleroderma , it is unclear whether the GI involvement secondary to scleroderma is influenced by these environmental factors . This study reviews the association between GI involvement and environmental and other exposures in patients with scleroderma. These findings will help patients with scleroderma and healthcare professionals in preventing GI morbidity. In Canada, the average annual economic burden of scleroderma is estimated to be $18,453 per patient . Knowing that the cost of care for patients with scleroderma increases with more organ involvement, the findings from this study can inform policy developers to identify ways to curb healthcare costs . The objective of this systematic review was to determine the factors associated with development of GI problems in patients with scleroderma.
Criteria for inclusion of studies
Design and time frame
Observational studies from June 1884 to May 2014 were considered in this review. June 1884 was chosen because it is the earliest entry of scleroderma in available databases.
The exposures of interest were silica, silicone implantation and rupture, antacid, solvents, epoxy resins, welding fumes, anorexigens, pentazocine, bromocriptine, l-tryptophan, pesticides, constant hand/arm vibration, alcohol, intestinal microbiota, and food along with any other reported risk factors [14–19].
Outcomes of interest included any reported GI problems such as nausea, vomiting, and diarrhea.
Search methods for identification of studies
Search strategy of MEDLINE via Ovid
Database: Ovid MEDLINE(R)
exp scleroderma, systemic/
exp scleroderma, localized/
((factor$ or feature$ or aspect$ or characteristic$) adj4 (risk)).mp.
exp silicon dioxide/
exp epoxy resins/
welding fume$ or welding gas*.mp.
exp anorexigenic drugs/
hand vibration or arm vibration.mp.
exp alcohol drinking/
exp gastrointestinal tract/
exp gastrointestinal diseases/
((problem$ or issue$ or concern$ or complication$) adj3 (alimentary canal or alimentary tract or digestive tube or digestive tract or GI tract)).mp.
exp weight loss/
uninten** weight loss.mp.
((uninten**) adj3 (weight loss)).mp.
poor appetite or limited appetite or reduced appetite or sparse appetite.mp. 34. ((poor or limited or reduced or sparse) adj3 (appetite)).mp.
exp deglutition disorders/
dysphagia or swallowing disorders.mp.
exp gastroesophageal reflux/
exp colonic pseudo-obstruction/
exp duodenal obstruction/
exp intestinal obstruction/
exp intestinal pseudo-obstruction/
bloat* or disten* or bulg* or enlarg* or expan*.mp.
((use or prescri** or administ**) adj2 (antibiotic$ or antibacterial$ or antimicrobial$)).mp.
exp fecal incontinence/
exp parenteral nutrition/
5 and 24 and 54
Cumulative Index to Nursing and Allied Health Literature (CINAHL), Excerpta Medica database (EMBASE), Latin American and Caribbean Health Sciences Literature (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE), and Web of Science were searched to identify relevant citations for this systematic review.
Other sources searched
We manually checked the reference lists of studies identified in an attempt to identify additional publications. Conference websites were not separately searched because EMBASE catalogues abstracts from several notable rheumatology conferences. A practicing rheumatologist and also an author of this review (ML) was queried to identify additional studies. We searched the Scleroderma Society of Canada, the Scleroderma Foundation, and the Scleroderma Research Foundation websites.
Study screening, selection, and assessment of methodological quality
Two authors (BYH and RJ), working independently, reviewed all citations and abstracts resulting from the search strategy to identify eligible papers. The full text of eligible articles were obtained and assessed independently using a pre-designed eligibility form based on the inclusion criteria. Eligible studies were included in the review. Disagreements were resolved by discussion or by seeking the opinion of a third party (LT/ML). The two authors (BYH and RJ) independently assessed the methodological quality of included studies using the Newcastle-Ottawa Scale and extracted data using a pre-established data extraction form .
We planned to pool the results using the DerSimmonian and Laird random effects method if there was a measure of relative risk (risk ratio, odds ratio, hazard ratio) and precision (95 % confidence intervals, standard error, variance) and if there was sufficient clinical and statistical homogeneity , and present the results as an odds ratios with 95 % confidence interval and p values. Between-study heterogeneity was also to be tested using Cochran’s Q and the I2 statistic. However, given the considerable clinical and design heterogeneity in the included studies, we adopted a narrative approach to summarize our findings.
Results of search
Overview of study characteristics and summary of study findings
There were three studies included in this systematic review, conducted in Japan, Canada, and Croatia in 2008, 2011, and 2013, respectively [24–26]. The number of enrolled patients ranged from 42 to 606 with the total of 712 patients included in this systematic review [24–26]. All three citations were cross-sectional studies [24–26]. Although all three studies examined GI problems as the outcome of interest, only one used endoscopic examination to diagnose reflux esophagitis , while the other two relied on self-reported severity of GI problems. Two studies examined Helicobacter pylori as a risk factor for GI problems in patients with scleroderma but gave contrasting results [24, 26]. The three included studies are summarised in Table 3.
Yamaguchi et al. 
The study by Yamaguchi et al. was a cross-sectional study that examined whether or not the presence of H. pylori infection was associated with reflux esophagitis in patients with scleroderma. Of the 138 patients with scleroderma, 74 were excluded because they were taking medications for their GI issues or had laparotomy. Of the remaining 64 patients (mean age = 60.7 years, % female 81.3, % diffuse disease 17), 37 were H. pylori positive. Without adjusting for covariates, it was found that being H. pylori positive is protective against reflux esophagitis in patients with scleroderma (OR = 0.16, 95 % CI = 0.05–0.47).
Hudson et al. 
The study by Hudson et al. was also a cross-sectional study, which examined whether smoking (never, past, or current) was associated with GI problems in patients with scleroderma. It examined the presence of 14 different GI problems and the severity of GI symptoms. Six hundred and six patients (mean age = 55.3 years, % female 87, % diffuse disease 36) were included in the analysis. Adjusted for covariates (age, gender, ethnicity, disease duration, diffuse disease), the regression model showed that only the number of GI symptoms and poor appetite showed statistical significant worsening with smoking.
Radic et al. 
The study by Radic et al. was another cross-sectional study that examined whether or not the presence of H. pylori infection was associated with self-reported GI problems in patients with scleroderma. Of the 42 patients (mean age = 54.3 years, % female 90.5, % diffuse disease 95.3), 26 were H. pylori positive. An adjusted analysis revealed that being H. pylori positive is correlated with high prevalence of GI issues.
Methodological quality of included studies
Methodological quality of included studies (Newcastle-Ottawa Scale)
Representativeness of the exposed cohort
Selection of the non-exposed cohort
Ascertainment of exposure
Outcome of interest not present at start of study
Assessment of outcome
Adequacy of duration of follow-up
Adequacy of completeness of follow-up
Yamaguchi et al. 
Hudson et al. 
Radic et al. 
Summary of main findings
Summary of included studies
Yamaguchi et al. 
Oct 1998–June 2005
n = 64
Mean, range = 60.7, 24–85
Disease duration (<1 year, <5, <10, >10): n = 19, n = 17, n = 18, n = 10
H. pylori: positive (n = 37), negative (n = 27)
H. pylori positive
% reflux esophagitis 27
% diffuse disease 17
H. pylori negative
% smoking 30
% reflux esophagitis 70
% alcohol 34
% corticosteroid use 72
Hudson et al. 
Aug 2004–Nov 2009
n = 606
Mean, SD = 55, 12
% Caucasian: 87.0
Smoking status: never (n = 255), past (n = 252; mean pack-years of smoking = 17, SD = 18), current (n = 99; mean pack-years of smoking = 25, SD = 17)
Disease duration (mean, SD): 11, 9
Mean severity of GI symptoms: 1.61 out of 10
Mean severity of GI symptoms: 2.18 out of 10
% diffuse disease 36.0
Mean number of GI symptoms: 3.99 out of 14a
Mean number of GI symptoms: 4.91 out of 14a
% poor appetite 28.6a
% poor appetite 47.5a
% difficulty swallowing 54.1
% difficulty swallowing 59.6
% acid reflux 60.8
% acid reflux 68.7
% nocturnal choking 28.6
% nocturnal choking 29.3
% heartburn 41.6
% heartburn 54.5
% early satiety 38.8
% early satiety 51.5
% abdominal bloating 34.9
% abdominal bloating 43.4
% nausea and vomiting 14.1
% nausea and vomiting 23.2
% chronic constipation 25.5
% chronic constipation 32.3
% chronic diarrhea 23.9
% chronic diarrhea 26.3
% antibiotics for bacterial overgrowth 7.5
% antibiotics for bacterial overgrowth 6.1
% greasy stools 18.8
% greasy stools 24.2
% fecal incontinence 19.2
% fecal incontinence 22.2
% parenteral nutrition 2.4
% parenteral nutrition 2.0
% taking medications for GI symptoms 73.7
% taking medications for GI symptoms 59.6
% taking medications for GI symptoms 67.1
Radic et al. 
Jan 2009–Dec 2010
n = 42
Mean, SD = 54.3, 13.6
Disease duration (median, range): 6, 1–43 years
H. pylori: positive (n = 26), negative (n = 16)
H. pylori positive
% GI problems 85
% diffuse disease 95.3
H. pylori negative
% GI problems 31
There are limitations to be noted in our systematic review. First, while our search did not include the gray literature, we undertook a thorough and rigorous search of CINAHL, EMBASE, GI, LILACS, and MEDLINE. Second, the extent of available data with regards to covariates was limited and the length of follow-up was often not specified, which may not be adequate for the observation of GI problems in patients with scleroderma. Third, all three studies are cross-sectional, which are not useful in determining predictors of outcome. These deficiencies highlight the need for further research to address the current knowledge gap exploring the risk factors associated with GI problems in patients with scleroderma.
Implications for practice
There is not enough evidence to inform clinical practice. This paper included three studies that report H. pylori infection (two studies) and smoking (one study) as potential risk factors for GI problems in patients with scleroderma. Given that the evidence is sparse and generally of low quality and that the two included studies on H. pylori contradict each other. It is unclear how to incorporate these findings into clinical practice. Smoking, however, seems to be associated with a wide range of GI problems.
Implications for research
In the field of scleroderma, longitudinal observational studies are warranted to investigate the risk factors for GI problems. For rare exposures like silica and pesticides, case-control designs may be more appropriate. A wealth of useful information can also be obtained from well-kept scleroderma registries. The studies should include patients with scleroderma followed up prior to and after the development of GI problems. Data on all potential risk factors including H. pylori infection, smoking, exposure to environmental toxins, and others should be collected. All possible GI problems should be explored, including data on morbidity and mortality.
There is a lack of evidence to conclusively suggest or refute whether H. pylori infection or smoking is a definitive risk factor for developing GI problems in patients with scleroderma.
Cumulative Index to Nursing and Allied Health Literature
Excerpta Medica Database
Latin American and Caribbean Health Sciences Literature
Medical Literature Analysis and Retrieval System Online
We thank Lois Cottrell for her assistance in developing and conducting the literature search.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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